Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada, V5Z 1M9, BC, 2775 Laurel Street, 7th Floor.
Lung. 2020 Dec;198(6):939-945. doi: 10.1007/s00408-020-00401-x. Epub 2020 Nov 3.
To investigate the relationship between obstructive sleep apnea (OSA) severity, body mass index (BMI), and circulating levels of inflammatory adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin).
A cross-sectional clinical cohort study on all consecutive adults referred to the University of British Columbia (UBC) Sleep Laboratory for a polysomnogram (PSG) for suspected OSA provided a morning blood sample. Samples were analyzed with multiplex immune assay (MilliporeSigma, CA) to assess the levels of adhesion molecules.
488 patients were studied; the majority were male (68%) with a mean age of 50 yrs, mean AHI of 23 events/hour, and mean BMI of 32 kg/m. In multivariable linear regression models, all three adhesion molecules were significantly associated with BMI (E-selectin p < 0.0001; ICAM-1 p = 0.0007; VCAM-1 p = 0.0003). However, only E-selectin was independently associated with AHI (p = 0.02); there was no significant interaction between AHI and BMI for E-selectin (p = 0.33).
Although all three adhesion molecules were associated with BMI, only E-selectin was independently associated with OSA severity. Future studies are needed to determine the clinical significance of the relationship between E-selectin and OSA.
研究阻塞性睡眠呼吸暂停（OSA）严重程度、体重指数（BMI）与循环中炎症黏附分子（细胞间黏附分子-1、血管细胞黏附分子-1 和 E-选择素）之间的关系。
对所有连续因疑似 OSA 而被转至不列颠哥伦比亚大学（UBC）睡眠实验室进行多导睡眠图（PSG）的成年人进行了一项横断面临床队列研究，提供了早晨血样。采用多重免疫分析法（密理博西格玛，加利福尼亚）分析样本，以评估黏附分子的水平。
研究了 488 例患者；大多数为男性（68%），平均年龄为 50 岁，平均 AHI 为 23 次/小时，平均 BMI 为 32kg/m。在多变量线性回归模型中，三种黏附分子均与 BMI 显著相关（E-选择素 p<0.0001；ICAM-1 p=0.0007；VCAM-1 p=0.0003）。然而，只有 E-选择素与 AHI 独立相关（p=0.02）；E-选择素与 BMI 之间没有显著的交互作用（p=0.33）。
尽管三种黏附分子均与 BMI 相关，但只有 E-选择素与 OSA 严重程度独立相关。需要进一步的研究来确定 E-选择素与 OSA 之间关系的临床意义。
