Department of Anesthesiology and Intensive Care Unit, Nord Hospital, Assistance Publique Hôpitaux Universitaire de Marseille, Aix Marseille University, Marseille, France.
MEPHI, IHU Méditerranée Infection, Aix Marseille Université, Marseille, France.
PLoS One. 2020 Nov 3;15(11):e0241827. doi: 10.1371/journal.pone.0241827. eCollection 2020.
Epidemiological differences between men and women have been reported with regards to sepsis, influenza and severe coronavirus infections including SARS-CoV and MERS-CoV.
To systematically review the literature relating to men versus women on SARS-CoV-2 in order to seek differences in disease characteristics (e.g. infectivity, severity) and outcomes (e.g. mortality).
We searched 3 electronic databases up or observational studies reporting differences between men and women in the SARS-CoV-2 disease characteristics stated. We identified and included 47 studies, reporting data for 21,454 patients mainly from China.
The unadjusted mortality rates of men were higher than those of women, with a mortality OR 0.51 [0.42, 0.61] (p<0.001) for women. The proportion of men presenting with severe disease and admitted to the intensive care unit (ICU) was also higher than that of women (OR 0.75 [0.60-0.93] p<0.001 and OR 0.45 [0.40-0.52] p<0.001 respectively). Adjusted analyses could not be conducted due to lack of data.
COVID-19 may be associated with worse outcomes in males than in females. However, until more detailed data are provided in further studies enabling adjusted analysis, this remains an unproven assumption.
已有研究报道，在脓毒症、流感和严重冠状病毒感染（包括 SARS-CoV 和 MERS-CoV）方面，男性和女性之间存在流行病学差异。
系统综述关于 SARS-CoV-2 男性与女性之间差异的文献，以探讨疾病特征（如传染性、严重程度）和结局（如死亡率）方面的差异。
我们检索了 3 个电子数据库，纳入了报告 SARS-CoV-2 疾病特征方面男性与女性存在差异的观察性研究。我们确定并纳入了 47 项研究，这些研究报告了主要来自中国的 21454 例患者的数据。
未经调整的男性死亡率高于女性，女性的死亡率比值比（OR）为 0.51 [0.42, 0.61]（p<0.001）。男性出现重症和入住重症监护病房（ICU）的比例也高于女性（OR 0.75 [0.60-0.93]，p<0.001 和 OR 0.45 [0.40-0.52]，p<0.001）。由于数据缺乏，无法进行调整分析。
COVID-19 可能与男性的结局较女性更差相关。然而，在进一步的研究中提供更详细的数据并进行调整分析之前，这仍然是一个未经证实的假设。
