Roszkowski K, Ko H L, van der Waaij D, Roszkowski W, Jeljaszewicz J, Pulverer G
Institute of Lung Diseases, Warsaw, Poland.
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Jul;265(3-4):378-84. doi: 10.1016/s0176-6724(87)80256-0.
The present paper deals with the influence of a 10 days treatment with mezlocillin, piperacillin, cefotaxime, clindamycin or gentamicin on the endogenous intestinal microflora of Balb/c-mice and on the local growth of sarcoma L-1 tumor. Clindamycin and gentamicin demonstrated no influence, whereas cefotaxime and piperacillin caused the eradication of gram-negative resp. gram-positive bacteria but these antibiotics didn't produce a growth inhibition of local L-1 sarcoma tumor. The oral or parenteral application of mezlocillin (a 3 days treatment was sufficient) eradicated the complete aerobic and anaerobic intestinal microflora. This effect was significantly correlated with an increase of the cecum weight and the inhibition of local tumor growth. Possible mechanisms of these effects are discussed.
本文探讨了美洛西林、哌拉西林、头孢噻肟、克林霉素或庆大霉素进行10天治疗对Balb/c小鼠肠道内源性微生物群以及肉瘤L-1肿瘤局部生长的影响。克林霉素和庆大霉素未显示出影响，而头孢噻肟和哌拉西林导致革兰氏阴性菌和革兰氏阳性菌的根除，但这些抗生素并未对局部L-1肉瘤肿瘤产生生长抑制作用。口服或肠胃外应用美洛西林（3天治疗就足够）可根除整个需氧和厌氧肠道微生物群。这种效应与盲肠重量增加和局部肿瘤生长抑制显著相关。文中讨论了这些效应可能的机制。
