Roszkowski W, Ko H L, Roszkowski K, Jeljaszewicz J, Pulverer G
Med Microbiol Immunol. 1985;173(5):279-89. doi: 10.1007/BF02124944.
The effects of 7 days' chemotherapy on the humoral and cellular parameters of the host immune system are described. In Balb/c mice the effects of cefotaxime, amikacin, mezlocillin, piperacillin and clindamycin were examined. The delayed-type hypersensitivity reaction, as well as the IgM and IgG responses, were suppressed by four of the five drugs tested: cefotaxime, amikacin, mezlocillin and piperacillin. One to two weeks after completion of chemotherapy with cefotaxime and amikacin, these parameters returned to normal values, whereas the mezlocillin- or piperacillin-modified reactions were still suppressed after 20 days. The concanavalin A and lipopolysaccharide-induced proliferative activities of mouse spleen cells were suppressed, especially by mezlocillin. The possible consequences of the immunomodulating effects of antibiotics for antimicrobial chemotherapy are discussed.
本文描述了为期7天的化疗对宿主免疫系统体液和细胞参数的影响。在Balb/c小鼠中，研究了头孢噻肟、阿米卡星、美洛西林、哌拉西林和克林霉素的作用。所测试的五种药物中的四种（头孢噻肟、阿米卡星、美洛西林和哌拉西林）抑制了迟发型超敏反应以及IgM和IgG反应。在用头孢噻肟和阿米卡星完成化疗一至两周后，这些参数恢复到正常水平，而美洛西林或哌拉西林引起的反应在20天后仍受到抑制。刀豆球蛋白A和脂多糖诱导的小鼠脾细胞增殖活性受到抑制，尤其是美洛西林。讨论了抗生素免疫调节作用对抗菌化疗可能产生的后果。
