Roszkowski K, Ko H L, Roszkowski W, Jeljaszewicz J, Pulverer G
Cancer Immunol Immunother. 1984;18(3):164-8. doi: 10.1007/BF00205506.
For the study described in the paper, the effects of 10 days' chemotherapy with cefotaxime, clindamycin, mezlocillin, and piperacillin on local tumor growth and on spontaneous or artificial metastatic spread into the lungs were studied. For the animal tumor model Balb/c mice and the mouse sarcoma L-1 tumor were used. Chemotherapy was administered before, immediately after, or some time after the injection of tumor cells. The antibiotic dosage given to mice was calculated on a body weight basis from the doses recommended for humans. Cefotaxime and clindamycin did not influence the animal tumor model, whereas mezlocillin and piperacillin showed positive or negative effects depending on the chemotherapy schedule. In vitro none of the four antibiotics caused cytotoxic activity in cell cultures of mouse sarcoma L-1, human lung cancer E-14, or human malignant melanoma MEW.
在该论文所描述的研究中，研究了用头孢噻肟、克林霉素、美洛西林和哌拉西林进行10天化疗对局部肿瘤生长以及对自发或人工转移至肺部的影响。使用了动物肿瘤模型Balb/c小鼠和小鼠肉瘤L-1肿瘤。在注射肿瘤细胞之前、之后立即或之后的某个时间进行化疗。给予小鼠的抗生素剂量是根据人体推荐剂量按体重计算的。头孢噻肟和克林霉素对动物肿瘤模型没有影响，而美洛西林和哌拉西林根据化疗方案显示出积极或消极的影响。在体外，这四种抗生素在小鼠肉瘤L-1、人肺癌E-14或人恶性黑色素瘤MEW的细胞培养物中均未引起细胞毒性活性。
