使用与牛血清白蛋白偶联的分离荚膜抗原预防大鼠由大肠杆菌引起的急性上行性肾盂肾炎。
Protection against acute, ascending pyelonephritis caused by Escherichia coli in rats, using isolated capsular antigen conjugated to bovine serum albumin.
作者信息
Kaijser B, Larsson P, Olling S, Schneerson R
出版信息
Infect Immun. 1983 Jan;39(1):142-6. doi: 10.1128/iai.39.1.142-146.1983.
Abstract
We found that isolated Escherichia coli K13 antigen conjugated to bovine serum albumin, in contrast to isolated, non-conjugated K13, was highly immunogenic and induced protection against acute pyelonephritis caused by E. coli O6K13H1 in rats.
摘要
我们发现，与分离出的未结合的K13抗原相比，与牛血清白蛋白结合的分离出的大肠杆菌K13抗原具有高度免疫原性，并能诱导大鼠抵抗由大肠杆菌O6K13H1引起的急性肾盂肾炎。
相似文献
1
Protection against acute, ascending pyelonephritis caused by Escherichia coli in rats, using isolated capsular antigen conjugated to bovine serum albumin.使用与牛血清白蛋白偶联的分离荚膜抗原预防大鼠由大肠杆菌引起的急性上行性肾盂肾炎。
Infect Immun. 1983 Jan;39(1):142-6. doi: 10.1128/iai.39.1.142-146.1983.
2
Protection against ascending Escherichia coli pyelonephritis in rats and significance of local immunity.大鼠上行性大肠杆菌肾盂肾炎的预防及局部免疫的意义
Infect Immun. 1978 Apr;20(1):78-81. doi: 10.1128/iai.20.1.78-81.1978.
3
4
Effect of immunization with Escherichia coli K1 antigen on the course of experimental infection of the urinary tract of the rat.用大肠杆菌K1抗原免疫对大鼠尿道实验性感染病程的影响。
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Jul;265(3-4):408-19. doi: 10.1016/s0176-6724(87)80260-2.
5
Protective efficacy and immunogenicity of Escherichia coli K13 diphtheria toxoid conjugate against experimental ascending pyelonephritis.大肠杆菌K13白喉类毒素结合物对实验性上行性肾盂肾炎的保护效力和免疫原性
Med Microbiol Immunol. 2005 Aug;194(4):211-7. doi: 10.1007/s00430-005-0241-x. Epub 2005 May 21.
6
Experimental Escherichia coli ascending pyelonephritis in rats: active peroral immunization with live Escherichia coli.大鼠实验性大肠杆菌上行性肾盂肾炎：用活大肠杆菌进行主动口服免疫
Infect Immun. 1982 Feb;35(2):647-53. doi: 10.1128/iai.35.2.647-653.1982.
7
Antibodies to Escherichia coli K and O antigens in protection against acute pyelonephritis.针对大肠杆菌K抗原和O抗原的抗体在预防急性肾盂肾炎中的作用。
Prog Allergy. 1983;33:275-88. doi: 10.1159/000318336.
8
Studies on immunity against Escherichia coli K13 with monoclonal anti-K13 and anti-anti-K13.利用抗K13单克隆抗体和抗抗K13抗体对大肠杆菌K13免疫的研究。
Infection. 1985;13 Suppl 2:S256-9. doi: 10.1007/BF01644440.
9
Protective effect of immunization with Salmonella minnesota Re 595 against ascending Escherichia coli O6K13H1 pyelonephritis in rats.
Scand J Infect Dis Suppl. 1980;Suppl 24:220-3.
10
Studies on immunity against Escherichia coli K13 with monoclonal anti-K13 and anti-anti-K13.利用抗K13单克隆抗体和抗抗K13抗体对大肠杆菌K13免疫的研究。
Infection. 1984 Jul-Aug;12(4):309-12. doi: 10.1007/BF01645972.
引用本文的文献
1
Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae.肠杆菌科细菌中的抗菌药物耐药性与疫苗，包括肠外致病性大肠杆菌和肺炎克雷伯菌。
NPJ Antimicrob Resist. 2025 Apr 28;3(1):34. doi: 10.1038/s44259-025-00100-8.
2
Vaccines against extraintestinal pathogenic (ExPEC): progress and challenges.针对肠外致病性大肠杆菌（ExPEC）的疫苗：进展与挑战。
Gut Microbes. 2024 Jan-Dec;16(1):2359691. doi: 10.1080/19490976.2024.2359691. Epub 2024 Jun 2.
3
Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections.用于治疗尿路感染的抗生素替代治疗选择
Front Microbiol. 2020 Jul 3;11:1509. doi: 10.3389/fmicb.2020.01509. eCollection 2020.
4
Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections.用于治疗和预防尿路感染的药物与疫苗研发
Microbiol Spectr. 2016 Feb;4(1). doi: 10.1128/microbiolspec.UTI-0013-2012.
5
Preventing urinary tract infection: progress toward an effective Escherichia coli vaccine.预防尿路感染：朝着有效的大肠杆菌疫苗迈进。
Expert Rev Vaccines. 2012 Jun;11(6):663-76. doi: 10.1586/erv.12.36.
6
Extraintestinal pathogenic Escherichia coli as a cause of invasive nonurinary infections.肠外致病性大肠埃希菌作为侵袭性非泌尿系统感染的病因
J Clin Microbiol. 2003 Dec;41(12):5798-802. doi: 10.1128/JCM.41.12.5798-5802.2003.
7
Non-antibiotic prevention of urinary tract infection.非抗生素预防尿路感染。
Infection. 1984 Mar-Apr;12(2):132-7. doi: 10.1007/BF01641697.
8
Serum antibody responses of juvenile and infant rhesus monkeys injected with Haemophilus influenzae type b and pneumococcus type 6A capsular polysaccharide-protein conjugates.注射b型流感嗜血杆菌和6A 型肺炎球菌荚膜多糖-蛋白结合物的幼年和婴儿恒河猴的血清抗体反应。
Infect Immun. 1984 Sep;45(3):582-91. doi: 10.1128/iai.45.3.582-591.1984.
9
Escherichia coli K5 antigen in relation to various infections and in healthy individuals.与各种感染及健康个体相关的大肠杆菌K5抗原
J Clin Microbiol. 1984 Feb;19(2):264-6. doi: 10.1128/jcm.19.2.264-266.1984.
10
Non-antibiotic prevention of urinary tract infection.非抗生素预防尿路感染
Infection. 1985;13 Suppl 2:S196-201. doi: 10.1007/BF01644430.
本文引用的文献
1
The role of immunity in the pathogenesis of experimental hematogenous pyelonephritis.免疫在实验性血源性肾盂肾炎发病机制中的作用。
J Exp Med. 1962 Feb 1;115(2):383-410. doi: 10.1084/jem.115.2.383.
2
Studies on the K antibody response in rabbits immunized with a pool of five different K antigen-containing Escherichia coli.对用五种不同含K抗原的大肠杆菌混合株免疫的兔子的K抗体反应的研究。
Int Arch Allergy Appl Immunol. 1981;65(3):300-3. doi: 10.1159/000232769.
3
An experimental model for ascending acute pyelonephritis caused by Escherichia coli or proteus in rats.大鼠由大肠杆菌或变形杆菌引起的上行性急性肾盂肾炎的实验模型。
J Clin Pathol. 1980 Apr;33(4):408-12. doi: 10.1136/jcp.33.4.408.
4
Preparation, characterization, and immunogenicity of Haemophilus influenzae type b polysaccharide-protein conjugates.b型流感嗜血杆菌多糖-蛋白结合物的制备、表征及免疫原性
J Exp Med. 1980 Aug 1;152(2):361-76. doi: 10.1084/jem.152.2.361.
5
Epidemiology of symptomatic urinary tract infection in childhood.儿童有症状性尿路感染的流行病学
Acta Paediatr Scand Suppl. 1974(252):1-20. doi: 10.1111/j.1651-2227.1974.tb05718.x.
6
7
Experimental hematogenous pyelonephritis due to Escherichia coli in rabbits: the antibody response and its protective capacity.兔源大肠杆菌所致实验性血源性肾盂肾炎：抗体反应及其保护能力
J Infect Dis. 1973 Jul;128(1):41-9. doi: 10.1093/infdis/128.1.41.
8
9
Escherichia coli K antigen.大肠杆菌K抗原
Zentralbl Bakteriol Orig A. 1979 Apr;243(2-3):271-88.
10
Protection against ascending Escherichia coli pyelonephritis in rats and significance of local immunity.大鼠上行性大肠杆菌肾盂肾炎的预防及局部免疫的意义
Infect Immun. 1978 Apr;20(1):78-81. doi: 10.1128/iai.20.1.78-81.1978.
Zotero 插件