Stella F, Troccoli R, Stella C, Battistelli S, Biagioni S, Giardini C, Baronciani D, Manenti F
Institute of Human Anatomy, University of Rome, Italy.
Acta Cytol. 1987 Sep-Oct;31(5):615-9.
The role of urinary cytology in the early diagnosis of cyclosporin nephrotoxicity was studied in 20 bone marrow transplant recipients. There was an evident cyclosporin cytopathy in 35% of bone marrow transplant recipients examined, consisting mainly of degenerative and necrotic abnormalities in cells of the proximal convoluted tubules seen in urinary samples. These findings regressed to normal after reduction of the cyclosporin dose. Urinary cytology proved to be a useful method for the early diagnosis of cyclosporin nephrotoxicity.
对20例骨髓移植受者研究了尿细胞学检查在环孢素肾毒性早期诊断中的作用。在接受检查的骨髓移植受者中，35%存在明显的环孢素细胞病变，主要表现为尿样中可见的近端曲管细胞的退行性和坏死性异常。在减少环孢素剂量后，这些发现恢复正常。尿细胞学检查被证明是早期诊断环孢素肾毒性的一种有用方法。
