2019 年韩国国内养猪场分离的非洲猪瘟病毒及其遗传特征。
Isolation and Genetic Characterization of African Swine Fever Virus from Domestic Pig Farms in South Korea, 2019.
机构信息
Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon 39660, Korea.
出版信息
Viruses. 2020 Oct 30;12(11):1237. doi: 10.3390/v12111237.
On 17 September 2019, the first outbreak of African swine fever in a pig farm was confirmed in South Korea. By 9 October, 14 outbreaks of ASF in domestic pigs had been diagnosed in 4 cities/counties. We isolated viruses from all infected farms and performed genetic characterization. The phylogenetic analysis showed that all of fourteen ASFV isolates in South Korea belong to genotype II and serogroup 8. Additionally, all isolates had an intergenic region (IGR) II variant with additional tandem repeat sequences (TRSs) between the I73R and I329L genes and showed characteristics of central variable region (CVR) 1 of the B602L gene and IGR 1 of MGF 505 9R/10R genes. These are identical to the genetic characteristics of some European isolates and Chinese isolates.
2019 年 9 月 17 日，韩国首次确认在一家养猪场爆发非洲猪瘟。截至 10 月 9 日，已在 4 个市/县诊断出 14 起国内猪 ASF 疫情。我们从所有受感染的农场中分离出病毒并进行了遗传特征分析。系统进化分析表明，韩国的 14 株 ASF 分离株均属于基因型 II 和血清群 8。此外，所有分离株的 I73R 和 I329L 基因之间的基因间隔区（IGR）II 变体都具有额外的串联重复序列（TRSs），并表现出 B602L 基因 CVR1 和 MGF5059R/10R 基因 IGR1 的特征。这些与一些欧洲和中国分离株的遗传特征相同。
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