Fanoro Olufunto T, Oluwafemi Oluwatobi S
Centre for Nanomaterials Sciences Research, University of Johannesburg, Johannesburg 2028, South Africa.
Department of Chemical Sciences (Formerly Applied Chemistry), University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa.
Pharmaceutics. 2020 Oct 30;12(11):1044. doi: 10.3390/pharmaceutics12111044.
As the field of nanomedicine develops and tackles the recent surge in antibiotic resistance, there is a need to have an in-depth understanding and a synergistic view of research on the effectiveness of a metal nanoparticle (NP) as an antibacterial agent especially their mechanisms of action. The constant development of bacterial resistance has led scientists to develop novel antibiotic agents. Silver, gold and its bimetallic combination are one of the most promising metal NPs because they show strong antibacterial activity. In this review we discuss the mode of synthesis and the proposed mechanism of biocidal antibacterial activity of metal NPs. These mechanisms include DNA degradation, protein oxidation, generation of reactive oxygen species, lipid peroxidation, ATP depletion, damage of biomolecules and membrane interaction.
随着纳米医学领域的发展并应对近期抗生素耐药性的激增，有必要深入了解并以协同的视角看待金属纳米颗粒（NP）作为抗菌剂的有效性研究，尤其是其作用机制。细菌耐药性的不断发展促使科学家们开发新型抗生素。银、金及其双金属组合是最有前景的金属纳米颗粒之一，因为它们表现出强大的抗菌活性。在本综述中，我们讨论了金属纳米颗粒的合成方式及其杀菌抗菌活性的推测机制。这些机制包括DNA降解、蛋白质氧化、活性氧的产生、脂质过氧化、ATP耗竭、生物分子损伤和膜相互作用。
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