Department of Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
In Vivo. 2020 Nov-Dec;34(6):3619-3626. doi: 10.21873/invivo.12207.
BACKGROUND/AIM: Histone modification is associated with tumorigenesis and cancer progression. Recent studies have revealed the prognostic value of histone modification; however, its prognostic role in distal bile duct cancer remains unclear.
We analyzed the expression of H3K9me3, H4K20me3, and H3K36me3 and its correlation with survival outcomes in resected samples from 88 patients with distal bile duct cancer.
Low expression rates of H3K9me3, H4K20me3, and H3K36me3 were significantly associated with poor overall survival (p=0.003, 0.008, and 0.047, respectively) and event-free survival (p=0.03 for H3K9m3). Additionally, low-expression of H3K9me3 was an independent poor prognostic indicator (p<0.001; HR=7.85; 95% CI=2.693-22.883).
H3K9me3 was an independent poor prognostic factor in distal common bile duct cancer. Our results suggest that histone markers are potential prognostic markers and provide better management for patients at risk for an aggressive course of disease.
背景/目的：组蛋白修饰与肿瘤发生和癌症进展有关。最近的研究揭示了组蛋白修饰的预后价值；然而，其在远端胆管癌中的预后作用尚不清楚。
我们分析了 88 例远端胆管癌切除标本中 H3K9me3、H4K20me3 和 H3K36me3 的表达及其与生存结局的相关性。
H3K9me3、H4K20me3 和 H3K36me3 的低表达率与总生存期（p=0.003、0.008 和 0.047）和无事件生存期（p=0.03，H3K9m3）显著相关。此外，H3K9me3 的低表达是独立的不良预后指标（p<0.001；HR=7.85；95%CI=2.693-22.883）。
H3K9me3 是远端胆总管癌的独立不良预后因素。我们的结果表明，组蛋白标志物是潜在的预后标志物，可以为有侵袭性疾病风险的患者提供更好的管理。
