Department of Radiation Oncology, University of Lübeck, Lübeck, Germany
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
In Vivo. 2020 Nov-Dec;34(6):3627-3630. doi: 10.21873/invivo.12208.
BACKGROUND/AIM: The prognoses of patients with grade III gliomas require improvement, which may be achieved with personalized care. We aimed to identify prognostic factors to facilitate the process of treatment personalization.
Eight factors were analyzed for local tumor control and survival in 44 patients irradiated for grade III glioma. These factors included location and size of glioma, number of glioma sites, performance status, gender, age, neurosurgical intervention and chemotherapy.
In the Cox regression analyses, frontal location (risk ratio=4.41, p=0.048) and unifocal glioma (risk ratio=4.65, p=0.034) were associated with improved local control, and unifocal glioma with improved survival (risk ratio=6.12, p=0.033). In addition, trends for better survival were observed for frontal location (p=0.093), age ≤49 years (p=0.070), upfront resection (p=0.099) and chemotherapy (p=0.066) on univariate analyses.
Independent predictors of local tumor control and survival were identified that can be helpful for personalizing treatment and designing clinical trials.
背景/目的：需要改善 III 级胶质瘤患者的预后，这可以通过个性化护理来实现。我们旨在确定预后因素，以促进治疗个体化的进程。
对 44 例接受 III 级胶质瘤放疗的患者的局部肿瘤控制和生存情况进行了 8 个因素分析。这些因素包括胶质瘤的位置和大小、胶质瘤部位的数量、表现状态、性别、年龄、神经外科干预和化疗。
在 Cox 回归分析中，额叶位置（风险比=4.41，p=0.048）和单灶胶质瘤（风险比=4.65，p=0.034）与局部控制改善相关，而单灶胶质瘤与生存改善相关（风险比=6.12，p=0.033）。此外，单因素分析显示，额叶位置（p=0.093）、≤49 岁（p=0.070）、初始切除（p=0.099）和化疗（p=0.066）的生存趋势更好。
确定了局部肿瘤控制和生存的独立预测因素，这有助于治疗个体化和临床试验的设计。
