脑胶质瘤放疗后生存预后因素的再评估：对既往研究的补充分析。
Re-Evaluation of Prognostic Factors for Survival After Radiotherapy of Cerebral Gliomas: A Supplementary Analysis to a Previous Study.
机构信息
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Neurological Department, Zealand University Hospital, Roskilde, Denmark.
出版信息
Anticancer Res. 2020 Nov;40(11):6513-6515. doi: 10.21873/anticanres.14674.
BACKGROUND/AIM: Previously, we identified predictors of survival after irradiation of grade II-IV cerebral gliomas. In this supplementary analysis, survival was calculated in a more appropriate way than the original study.
PATIENTS AND METHODS
Ten factors were re-evaluated for survival in patients of the original study including pre-radiotherapy seizures. In the original study, survival was calculated from the end of the last radiotherapy course (primary or re-irradiation). After re-review, this approach was considered inappropriate. Survival should have always been calculated from the first radiotherapy course, as done in this supplementary analysis.
RESULTS
On multivariate analysis, WHO-grade II (p=0.006) and upfront resection (p=0.001) were associated with better survival. Unifocal glioma was significant on univariate analysis (p=0.001), where a trend could be identified for age ≤59 years (p=0.057) and seizures (p=0.060).
CONCLUSION
The findings of this supplementary analysis regarding the identification of prognostic factors for survival agree with the results of the original study.
背景/目的：此前，我们确定了 II-IV 级脑胶质瘤放疗后生存的预测因素。在本补充分析中，生存的计算方法比原始研究更恰当。
患者和方法
重新评估了原始研究中 10 个因素与生存的关系，包括放疗前的癫痫发作。在原始研究中，生存是从最后一次放疗疗程结束（初次或再放疗）开始计算的。重新审查后，认为这种方法不合适。本补充分析中，生存应始终从第一次放疗开始计算。
结果
多因素分析显示，WHO 分级 II 级（p=0.006）和初始切除（p=0.001）与更好的生存相关。单变量分析中单侧胶质瘤有显著意义（p=0.001），年龄≤59 岁（p=0.057）和癫痫发作（p=0.060）存在趋势。
结论
本补充分析中关于生存预后因素的发现与原始研究的结果一致。
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