Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.
In Vivo. 2020 Nov-Dec;34(6):3719-3722. doi: 10.21873/invivo.12220.
BACKGROUND/AIM: Personalized treatment for low-grade gliomas likely improves patient outcomes. This study aimed to identify predictors of local control and survival.
Twenty-five patients irradiated for grade II gliomas were retrospectively analyzed. Irradiation was performed after biopsy (n=6) or incomplete resection (n=19). Nineteen patients received additional chemotherapy. Eight factors were analyzed, namely the number of glioma sites, cumulative maximum diameter, radiotherapy technique, Karnofsky performance score (KPS), gender, age, resection and chemotherapy.
On univariate analysis, trends for associations with local control were found for cumulative maximum diameter ≤43 mm (p=0.087) and age ≤45 years (p=0.065). In the Cox regression analysis, cumulative maximum diameter maintained significance (p=0.046). On univariate analysis, KPS 90-100 (p=0.039) and female gender (p=0.022) were significantly associated with better survival. In the Cox regression analysis, both KPS (p=0.039) and gender (p=0.016) were significant.
Independent predictors of local control and survival were identified that can contribute to better treatment personalization.
背景/目的：个性化治疗低级别胶质瘤可能改善患者预后。本研究旨在确定局部控制和生存的预测因素。
回顾性分析了 25 名接受 II 级胶质瘤放疗的患者。放疗在活检后进行（n=6）或不完全切除后进行（n=19）。19 名患者接受了额外的化疗。分析了 8 个因素，即胶质瘤部位数量、累积最大直径、放疗技术、卡氏功能状态评分（KPS）、性别、年龄、切除和化疗。
单因素分析显示，累积最大直径≤43mm（p=0.087）和年龄≤45 岁（p=0.065）与局部控制呈趋势相关。在 Cox 回归分析中，累积最大直径仍有意义（p=0.046）。单因素分析显示，KPS 90-100（p=0.039）和女性（p=0.022）与更好的生存显著相关。在 Cox 回归分析中，KPS（p=0.039）和性别（p=0.016）均有统计学意义。
确定了局部控制和生存的独立预测因素，这有助于更好地实现治疗个体化。
