二甲双胍所致乳酸性酸中毒：时间问题
Metformin-Induced Lactic Acidosis: A Question of Time.
作者信息
Bellefroid Céline, Goffin Pierre, Guntz Julien, Deville Marine
机构信息
Department of Anesthesia and Intensive Care, MontLegia Hospital, Groupe Santé CHC, Liège, Belgium.
Laboratory of Clinical, Forensic, Industrial and Environmental Toxicology, Center for Interdisciplinary Research on Medicines, University Hospital of Liège, Liège, Belgium.
出版信息
Case Rep Crit Care. 2020 Oct 21;2020:6962591. doi: 10.1155/2020/6962591. eCollection 2020.
Metformin is an oral antidiabetic largely prescribed in the treatment of type II diabetes. Overdose is associated with life-threatening lactic acidosis. We report the case of the highest metformin concentration ever described secondary to a voluntary suicidal intake. The patient developed a severe lactic acidosis and hemodynamic shock successfully treated with high-flow hemofiltration. Time to start extrarenal epuration is capital to avoid poor evolution.
二甲双胍是一种常用于治疗II型糖尿病的口服抗糖尿病药物。过量服用会导致危及生命的乳酸性酸中毒。我们报告了一例因自愿自杀性服药导致的有史以来描述的最高二甲双胍浓度的病例。该患者发生了严重的乳酸性酸中毒和血流动力学休克，通过高流量血液滤过成功治疗。开始肾外净化的时机对于避免病情恶化至关重要。
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