Spithoven E M, Bruns A H W, Petri B J, Haas P J, Nguyen T Q, Hagen F, van Zuilen A D
Department of Nephrology, Internal Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Department of Infectious Diseases, Internal Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Med Mycol Case Rep. 2020 Oct 23;30:39-42. doi: 10.1016/j.mmcr.2020.10.002. eCollection 2020 Dec.
Mucormycosis is a life-threatening invasive fungal infection, most commonly described in severely immunocompromised patients. It is characterized by rapid invasive growth of the fungus and often with fatal outcome. We report a case of a renal transplant recipient diagnosed with a donor-derived invasive mucormycosis. In this patient, we used a step-wise approach of withdrawal of immunosuppressants, antifungal induction therapy, extensive surgical debridement of all (potentially) infected tissue, abdominal irrigation of liposomal amphotericin B and interferon gamma. Due to rapid diagnosis and intensive therapy the patient survived.
毛霉病是一种危及生命的侵袭性真菌感染，最常见于严重免疫功能低下的患者。其特征是真菌快速侵袭性生长，且往往导致致命后果。我们报告一例肾移植受者被诊断为供体来源的侵袭性毛霉病的病例。在该患者中，我们采用了逐步减少免疫抑制剂、抗真菌诱导治疗、对所有（可能）感染组织进行广泛手术清创、用脂质体两性霉素B和干扰素γ进行腹腔灌洗的方法。由于诊断迅速且治疗积极，患者得以存活。
