利用低成本啤酒厂废弃物生产表面活性素作为天然微生物杀生剂。
The use of low-cost brewery waste product for the production of surfactin as a natural microbial biocide.
作者信息
Nazareth Talita Corrêa, Zanutto Conrado Planas, Tripathi Lakshmi, Juma Abdulaziz, Maass Danielle, de Souza Antônio Augusto Ulson, de Arruda Guelli Ulson de Souza Selene Maria, Banat Ibrahim M
机构信息
Department of Chemical and Food Engineering (EQA), Federal University of Santa Catarina (UFSC), 88040-900 Florianópolis, SC, Brazil.
School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA Northern Ireland, UK.
出版信息
Biotechnol Rep (Amst). 2020 Oct 16;28:e00537. doi: 10.1016/j.btre.2020.e00537. eCollection 2020 Dec.
Surfactin has potential as next generation antibiofilm agent to combat antimicrobial resistance against emerging pathogens. However, the widespread industrial applications of surfactin is hampered by its high production cost. In this work, surfactin was produced from using a low-cost brewery waste as a carbon source. The strain produced 210.11 mg after 28 h. The antimicrobial activity was observed against all tested strains, achieving complete inhibition for , at 500 g mL . A growth log reduction of 3.91 was achieved for while, and showed between 1 and 2 log reductions. In the anti-biofilm assays against , the co-incubation, anti-adhesive and disruption showed inhibition, where the greatest inhibition was observed in the co-incubation assay (79.80%). This study provides evidence that surfactin produced from a low-cost substrate can be a promising biocide due to its antimicrobial and anti-biofilm abilities against pathogens.
表面活性素具有作为下一代抗生物膜剂的潜力，以对抗针对新兴病原体的抗菌耐药性。然而，表面活性素的广泛工业应用受到其高生产成本的阻碍。在这项工作中，使用低成本的啤酒厂废料作为碳源生产表面活性素。该菌株在28小时后产生了210.11毫克。观察到对所有测试菌株都有抗菌活性，在500微克/毫升时对金黄色葡萄球菌实现了完全抑制。对大肠杆菌实现了3.91的生长对数减少，而枯草芽孢杆菌和铜绿假单胞菌显示出1至2个对数减少。在针对金黄色葡萄球菌的抗生物膜试验中，共孵育、抗粘附和破坏试验均显示出抑制作用，其中在共孵育试验中观察到最大抑制率（79.80%）。这项研究提供了证据，表明由低成本底物生产的表面活性素因其对病原体的抗菌和抗生物膜能力而可能成为一种有前景的杀菌剂。
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