Wang Qixing, Liu Yuhao, Zhu Zhengfang, Hu Jian, Li Li, Wang Sheng
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Ann Transl Med. 2020 Sep;8(17):1072. doi: 10.21037/atm-20-1584.
Radionuclide imaging is the primary method of visually evaluating drug deposition in the lungs. Here, we used a new imaging technique, dual-source dual-energy computed tomography (DSDECT), to compare the ability of two nebulizers commonly used in clinical practice to deposit drugs in the lungs.
Male New Zealand White rabbits were randomly divided into a vibrating mesh nebulizer group and a small volume jet nebulizer group. First, two rabbits received methylene blue-iohexol-normal saline by inhalation to confirm that DSDECT was a feasible method of assessing aerosol inhalation. Then, 10 rabbits were subjected to DSDECT scan before and after receiving a iohexol-normal saline mixture by inhalation. All images were transferred and reconstructed on a workstation computer equipped with dedicated software.
DSDECT revealed the same iodine distribution as tracheobronchial methylene blue staining on dissection. Significant differences between the groups in average CT value and iodine concentration were noted in the right upper lobe (P<0.05), but no other lobes showed statistically significant differences. The regional distribution of drugs in different lobes of the lung varied by nebulizer.
DSDECT is a useful method of evaluating drug deposition in the lungs, and vibrating mesh nebulizers deposit more drugs than small volume jet nebulizers.
放射性核素成像 是直观评估药物在肺部沉积的主要方法。在此，我们使用一种新的成像技术，即双源双能计算机断层扫描（DSDECT），来比较临床实践中常用的两种雾化器在肺部沉积药物的能力。
将雄性新西兰白兔随机分为振动网式雾化器组和小容量喷射雾化器组。首先，对两只兔子进行吸入亚甲蓝 - 碘海醇 - 生理盐水操作，以确认DSDECT是评估气溶胶吸入的可行方法。然后，对10只兔子在吸入碘海醇 - 生理盐水混合物前后进行DSDECT扫描。所有图像都在配备专用软件的工作站计算机上进行传输和重建。
DSDECT显示的碘分布与解剖时气管支气管亚甲蓝染色结果相同。右上叶两组之间的平均CT值和碘浓度存在显著差异（P<0.05），但其他叶均未显示出统计学上的显著差异。不同雾化器在肺不同叶中的药物区域分布有所不同。
DSDECT是评估药物在肺部沉积的一种有用方法，且振动网式雾化器比小容量喷射雾化器沉积的药物更多。
