Expression Patterns and Prognostic Values of ORMDL1 in Different Cancers.

The mammalian orosomucoid-like gene family (), containing , , and , is the important regulator of sphingolipid metabolism, which is relevant to cell growth, proliferation, migration, and invasion. Since the role of in cancers remained unclear, the main purpose of our study was to explore the expression patterns and prognostic values of in different tumors, especially in cholangiocarcinoma (CHOL), lymphoid neoplasm diffuse large B cell lymphoma (DLBCL), acute myeloid leukemia (LAML), and thymoma (THYM). Bioinformatics tools including GEPIA, CCLE, LinkedOmics, cBioPortal, and TIMER databases were used. As a result, the expression levels of in tumor tissues and normal tissues varied in different cancers, especially significantly upregulated in CHOL, DLBCL, LAML, and THYM. Moreover, mRNA was also highly expressed in cell lines of DLBCL and LAML. Further studies showed that overexpression was associated with poor prognosis in DLBCL, but not significant in CHOL, LAML, and THYM. Consistently, there were genetic alterations of in DLBCL, and patients with genetic alterations indicated worse survival. Coexpressed genes and related biological events with in DLBCL were found via LinkedOmics, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. The relationship between and cancer immune cells was investigated, and expression was positively correlated with infiltrating levels of B cells. In conclusion, 1 is suggested to be a tumorigenic factor and considered as the potential therapeutic target and prognostic biomarker in DLBCL.