• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

转录因子E2F1/2/5/8作为潜在靶点，转录因子E2F3/6/7作为人肺癌预后的新生物标志物。

Transcriptional E2F1/2/5/8 as potential targets and transcriptional E2F3/6/7 as new biomarkers for the prognosis of human lung carcinoma.

作者信息

Sun Cheng-Cao, Zhou Qun, Hu Wei, Li Shu-Jun, Zhang Feng, Chen Zhen-Long, Li Guang, Bi Zhuo-Yue, Bi Yong-Yi, Gong Feng-Yun, Bo Tao, Yuan Zhan-Peng, Hu Wei-Dong, Zhan Bo-Tao, Zhang Qian, Tang Qi-Zhu, Li De-Jia

机构信息

Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. China.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

Aging (Albany NY). 2018 May 11;10(5):973-987. doi: 10.18632/aging.101441.

DOI:10.18632/aging.101441
PMID:29754146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5990399/
Abstract

E2F is a group of genes that encode a family of transcription factors (TFs) in higher eukaryotes and participate in cell cycle regulation and DNA synthesis in mammalian cells. Evidence from cell lines, mouse models, and human tissues indicates that TFs are implicated in lung cancer (LC) tumorigenesis. However, the diverse expression patterns and prognostic values of eight E2Fs have yet to be elucidated. In the current study, we examined the transcriptional and survival data of E2Fs in patients with LC from ONCOMINE, GEPIA, Kaplan-Meier Plotter, and cBioPortal databases. We found that the expression levels of E2F1/2/3/5/6/7/8 were higher in lung adenocarcinoma and squamous cell lung carcinoma tissues than in lung tissues, whereas the expression level of E2F4 was lower in the former than in the latter. The expression levels of E2F2/4/5/7/8 were correlated with advanced tumor stage. Survival analysis using the Kaplan-Meier Plotter database revealed that the high transcription levels of E2F1/2/4/5/7/8 were associated with low relapse-free survival (RFS) in all of the patients with LC. Conversely, high E2F3/6 levels predicted high RFS in these patients. This study implied that E2F3/6/7 are potential targets of precision therapy for patients with LC and that E2F1/2/4/5/8 are new biomarkers for the prognosis of LC.

摘要

E2F是一组在高等真核生物中编码转录因子（TFs）家族的基因，参与哺乳动物细胞的细胞周期调控和DNA合成。来自细胞系、小鼠模型和人体组织的证据表明，转录因子与肺癌（LC）的肿瘤发生有关。然而，八种E2F的不同表达模式和预后价值尚未阐明。在本研究中，我们从ONCOMINE、GEPIA、Kaplan-Meier Plotter和cBioPortal数据库中检查了LC患者中E2F的转录和生存数据。我们发现，E2F1/2/3/5/6/7/8在肺腺癌和肺鳞状细胞癌组织中的表达水平高于肺组织，而E2F4在前者中的表达水平低于后者。E2F2/4/5/7/8的表达水平与肿瘤晚期相关。使用Kaplan-Meier Plotter数据库进行的生存分析显示，E2F1/2/4/5/7/8的高转录水平与所有LC患者的低无复发生存期（RFS）相关。相反，E2F3/6的高表达水平预示着这些患者的高RFS。本研究表明，E2F3/6/7是LC患者精准治疗的潜在靶点，而E2F1/2/4/5/8是LC预后的新生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/e984675c73b6/aging-10-101441-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/df70bd2373d5/aging-10-101441-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/5bcde5923b75/aging-10-101441-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/2ef7fbd8ebd3/aging-10-101441-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/83508c666acf/aging-10-101441-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/298a66eafa37/aging-10-101441-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/e3120dbe9e18/aging-10-101441-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/e08b7b67531f/aging-10-101441-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/184313f1a9b7/aging-10-101441-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/e984675c73b6/aging-10-101441-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/df70bd2373d5/aging-10-101441-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/5bcde5923b75/aging-10-101441-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/2ef7fbd8ebd3/aging-10-101441-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/83508c666acf/aging-10-101441-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/298a66eafa37/aging-10-101441-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/e3120dbe9e18/aging-10-101441-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/e08b7b67531f/aging-10-101441-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/184313f1a9b7/aging-10-101441-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7329/5990399/e984675c73b6/aging-10-101441-g009.jpg

相似文献

1
Transcriptional E2F1/2/5/8 as potential targets and transcriptional E2F3/6/7 as new biomarkers for the prognosis of human lung carcinoma.转录因子E2F1/2/5/8作为潜在靶点，转录因子E2F3/6/7作为人肺癌预后的新生物标志物。
Aging (Albany NY). 2018 May 11;10(5):973-987. doi: 10.18632/aging.101441.
2
Expression and prognostic value of E2F activators in NSCLC and subtypes: a research based on bioinformatics analysis.E2F激活剂在非小细胞肺癌及其亚型中的表达与预后价值：一项基于生物信息学分析的研究
Tumour Biol. 2016 Nov;37(11):14979-14987. doi: 10.1007/s13277-016-5389-z. Epub 2016 Sep 21.
3
Analysis of the Expression of Genes and Its Prognostic Significance in Human Lung Carcinoma: A Review of the Literature Databases.分析人类肺癌中基因的表达及其预后意义：文献数据库综述。
Biomed Res Int. 2020 Feb 12;2020:6412593. doi: 10.1155/2020/6412593. eCollection 2020.
4
Expressions and prognostic values of the transcription factors in human breast carcinoma.转录因子在人乳腺癌中的表达及其预后价值
Cancer Manag Res. 2018 Sep 13;10:3521-3532. doi: 10.2147/CMAR.S172332. eCollection 2018.
5
Expression patterns of E2F transcription factors and their potential prognostic roles in breast cancer.E2F转录因子在乳腺癌中的表达模式及其潜在的预后作用。
Oncol Lett. 2018 Jun;15(6):9216-9230. doi: 10.3892/ol.2018.8514. Epub 2018 Apr 17.
6
The E2F family as potential biomarkers and therapeutic targets in colon cancer.E2F家族作为结肠癌潜在的生物标志物和治疗靶点。
PeerJ. 2020 Feb 19;8:e8562. doi: 10.7717/peerj.8562. eCollection 2020.
7
Combined analysis identifies six genes correlated with augmented malignancy from non-small cell to small cell lung cancer.联合分析确定了六个与非小细胞肺癌向小细胞肺癌恶性程度增加相关的基因。
Tumour Biol. 2016 Feb;37(2):2193-207. doi: 10.1007/s13277-015-3938-5. Epub 2015 Sep 9.
8
Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma.E2F 转录因子表达在胰腺导管腺癌中的预后价值。
Med Sci Monit. 2021 Nov 20;27:e933443. doi: 10.12659/MSM.933443.
9
The transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma.转录因子STAT3是一个潜在靶点，而转录因子STAT5A/5B/6是人类乳腺癌预后的新生物标志物。
Oncotarget. 2017 May 30;8(22):36279-36288. doi: 10.18632/oncotarget.16748.
10
Protein expression profiles and prognostic value of E2F family members in clear cell renal cell carcinoma.E2F 家族成员在肾透明细胞癌中的蛋白表达谱及其预后价值。
Pathol Res Pract. 2020 Apr;216(4):152880. doi: 10.1016/j.prp.2020.152880. Epub 2020 Feb 13.

引用本文的文献

1
Identification of a long non-coding RNA signature associated with cuproptosis for prognosis and immunotherapy response prediction in patients with lung adenocarcinoma.鉴定与铜死亡相关的长链非编码RNA特征用于预测肺腺癌患者的预后和免疫治疗反应
Discov Oncol. 2025 Mar 31;16(1):432. doi: 10.1007/s12672-025-02092-3.
2
Significance of in prognosis and tumor microenvironment of lung adenocarcinoma.[具体内容]在肺腺癌预后及肿瘤微环境中的意义
Front Pharmacol. 2025 Feb 25;16:1540636. doi: 10.3389/fphar.2025.1540636. eCollection 2025.
3
The role of E2F2 in cancer progression and its value as a therapeutic target.

本文引用的文献

1
MicroRNA-129-3p suppresses tumor growth by targeting E2F5 in glioblastoma.微小 RNA-129-3p 通过靶向神经胶质瘤中的 E2F5 抑制肿瘤生长。
Eur Rev Med Pharmacol Sci. 2018 Feb;22(4):1044-1050. doi: 10.26355/eurrev_201802_14387.
2
Identification of tumor suppressive role of microRNA-132 and its target gene in tumorigenesis of prostate cancer.鉴定 microRNA-132 及其靶基因在前列腺癌肿瘤发生中的肿瘤抑制作用。
Int J Mol Med. 2018 Apr;41(4):2429-2433. doi: 10.3892/ijmm.2018.3421. Epub 2018 Jan 23.
3
Metformin induces cell cycle arrest at the G1 phase through E2F8 suppression in lung cancer cells.
E2F2 在癌症进展中的作用及其作为治疗靶点的价值。
Front Immunol. 2024 May 14;15:1397303. doi: 10.3389/fimmu.2024.1397303. eCollection 2024.
4
A Novel Gene Signature based on Immune Cell Infiltration Landscape Predicts Prognosis in Lung Adenocarcinoma Patients.基于免疫细胞浸润景观的新型基因特征可预测肺腺癌患者的预后。
Curr Med Chem. 2024;31(38):6319-6335. doi: 10.2174/0109298673293174240320053546.
5
Brevilin A shows an anti-tumor role in prostate cancer via the lncRNA H19/miR-194/E2F3 signaling pathway.布瑞维林 A 通过长链非编码 RNA H19/miR-194/E2F3 信号通路在前列腺癌中发挥抗肿瘤作用。
Aging (Albany NY). 2023 May 30;15(10):4411-4428. doi: 10.18632/aging.204744.
6
Identifying General Tumor and Specific Lung Cancer Biomarkers by Transcriptomic Analysis.通过转录组分析鉴定通用肿瘤和特定肺癌生物标志物
Biology (Basel). 2022 Jul 20;11(7):1082. doi: 10.3390/biology11071082.
7
Glucosamine-phosphate N-acetyltransferase 1 and its DNA methylation can be biomarkers for the diagnosis and prognosis of lung cancer.葡萄糖胺-磷酸 N-乙酰转移酶 1 及其 DNA 甲基化可作为肺癌诊断和预后的生物标志物。
J Clin Lab Anal. 2022 Sep;36(9):e24628. doi: 10.1002/jcla.24628. Epub 2022 Aug 5.
8
Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.人类肉瘤中 GINS 家族基因的表达、预后和免疫浸润的综合分析。
Aging (Albany NY). 2022 Jul 27;14(14):5895-5907. doi: 10.18632/aging.204191.
9
LINC00265 Promotes Metastasis and Progression of Hepatocellular Carcinoma by Interacting with E2F1 at The Promoter of .LINC00265 通过在……启动子处与 E2F1 相互作用促进肝细胞癌的转移和进展 。 （原文此处不完整，“at The Promoter of.”后面应该还有具体基因等信息）
Cell J. 2022 Jun;24(6):294-301. doi: 10.22074/cellj.2022.8035. Epub 2022 Jun 29.
10
E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry.E2F2 通过促进 B-Myb 和 FOXM1 介导的核心转录调控回路促进肺腺癌的进展。
Int J Biol Sci. 2022 Jun 25;18(10):4151-4170. doi: 10.7150/ijbs.72386. eCollection 2022.
二甲双胍通过抑制肺癌细胞中的E2F8诱导细胞周期在G1期停滞。
Oncotarget. 2017 Oct 6;8(60):101509-101519. doi: 10.18632/oncotarget.21552. eCollection 2017 Nov 24.
4
Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer.转录因子 E2F1 通过调节小细胞肺癌中的 ZEB2 促进 EMT。
BMC Cancer. 2017 Nov 7;17(1):719. doi: 10.1186/s12885-017-3701-y.
5
miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.miR-99a 揭示了两个新的致癌蛋白 E2F2 和 EMR2，并抑制肺癌中的干细胞特性。
Cell Death Dis. 2017 Oct 26;8(10):e3141. doi: 10.1038/cddis.2017.544.
6
lncRNA-HIT promotes cell proliferation of non-small cell lung cancer by association with E2F1.lncRNA-HIT 通过与 E2F1 结合促进非小细胞肺癌细胞增殖。
Cancer Gene Ther. 2017 May;24(5):221-226. doi: 10.1038/cgt.2017.10. Epub 2017 Apr 21.
7
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.GEPIA：一个用于癌症和正常基因表达谱分析及交互式分析的网络服务器。
Nucleic Acids Res. 2017 Jul 3;45(W1):W98-W102. doi: 10.1093/nar/gkx247.
8
E2F3 transcription factor: A promising biomarker in lung cancer.E2F3转录因子：肺癌中一种有前景的生物标志物。
Cancer Biomark. 2017;19(1):21-26. doi: 10.3233/CBM-160196.
9
Long Intergenic Noncoding RNA 00511 Acts as an Oncogene in Non-small-cell Lung Cancer by Binding to EZH2 and Suppressing p57.长链基因间非编码RNA 00511通过与EZH2结合并抑制p57在非小细胞肺癌中发挥癌基因作用。
Mol Ther Nucleic Acids. 2016 Nov 15;5(11):e385. doi: 10.1038/mtna.2016.94.
10
Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression.长链非编码RNA XIST通过表观遗传抑制KLF2表达在非小细胞肺癌中发挥癌基因作用。
Biochem Biophys Res Commun. 2016 Sep 16;478(2):811-7. doi: 10.1016/j.bbrc.2016.08.030. Epub 2016 Aug 5.