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甲基化沉默 CDH23 是弥漫性大 B 细胞淋巴瘤的预后不良标志物。

Methylation silencing CDH23 is a poor prognostic marker in diffuse large B-cell lymphoma.

机构信息

Department of Lymphoma, Beijing Shijitan Hospital, Capital Medical University, Haidian 100038, Beijing, China.

出版信息

Aging (Albany NY). 2021 Jul 12;13(13):17768-17788. doi: 10.18632/aging.203268.

DOI:10.18632/aging.203268
PMID:34252883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8312441/
Abstract

Cadherin-23(CDH23) mediates homotypic and heterotypic cell-cell adhesions in cancer cells. However, the epigenetic regulation, the biological functions, the mechanisms and the prognostic value of CDH23 in diffuse large B-cell lymphoma (DLBCL) are still unclear. The Gene Expression Profiling Interactive Analysis (GEPIA) and the Gene Expression Omnibus (GEO) database were employed to analyze the CDH23 expression level in DLBCL. The correlation of CDH23 expression and methylation was analyzed by LinkedOmics database. The prognostic value was analyzed via GEPIA. Correlated genes, target kinase, target miRNA, target transcription factor and biological functions were identified by LinkedOmics and GeneMANIA database. The relationship between CDH23 and the immune cell infiltration was explored by the Tumor Immune Estimation Resource (TIMER). The expression of CDH23 was reduced by DNA methylation significantly in DLBCL tissue. Reduction of CDH23 represented poor outcome of DLBCL patients. Functional enrichment analysis showed that CDH23 mainly enriched in cancer cell growth, cell metastasis, cell adhesion, cell cycle, drug catabolic process, leukocyte mediated immunity and DNA repair by some cancer related kinases, miRNAs and transcription factors. These results indicated that methylated reduction of CDH23 represented poor outcome of DLBCL. CDH23 is associated with essential biological functions and key molecules in DLBCL. CDH23 may play crucial roles in DLBCL tumorigenesis. Our results lay a foundation for further investigation of the role of CDH23 in DLBCL tumorigenesis.

摘要

钙黏蛋白 23（CDH23）介导癌细胞的同质和异质细胞间黏附。然而，CDH23 在弥漫性大 B 细胞淋巴瘤（DLBCL）中的表观遗传调控、生物学功能、机制和预后价值尚不清楚。本研究通过基因表达谱交互分析（GEPIA）和基因表达综合数据库（GEO）数据库分析 CDH23 在 DLBCL 中的表达水平。通过 LinkedOmics 数据库分析 CDH23 表达与甲基化的相关性。通过 GEPIA 分析预后价值。通过 LinkedOmics 和 GeneMANIA 数据库鉴定相关基因、靶激酶、靶 miRNA、靶转录因子和生物学功能。通过肿瘤免疫估计资源（TIMER）探索 CDH23 与免疫细胞浸润的关系。CDH23 在 DLBCL 组织中因 DNA 甲基化而显著下调。CDH23 的下调代表 DLBCL 患者预后不良。功能富集分析表明，CDH23 主要富集在癌症细胞生长、细胞转移、细胞黏附、细胞周期、药物代谢过程、白细胞介导的免疫和 DNA 修复等方面，这些过程涉及一些癌症相关的激酶、miRNA 和转录因子。这些结果表明，CDH23 的甲基化下调代表了 DLBCL 预后不良。CDH23 与 DLBCL 中的基本生物学功能和关键分子相关。CDH23 可能在 DLBCL 肿瘤发生中发挥关键作用。我们的研究结果为进一步研究 CDH23 在 DLBCL 肿瘤发生中的作用奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/d948ebf9ec72/aging-13-203268-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/b99f9a73e4ea/aging-13-203268-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/1f172b7d2f7f/aging-13-203268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/5ff684731bea/aging-13-203268-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/0338be82486d/aging-13-203268-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/4c5b83b1926f/aging-13-203268-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/393f1ae72f22/aging-13-203268-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/d948ebf9ec72/aging-13-203268-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/b99f9a73e4ea/aging-13-203268-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/1f172b7d2f7f/aging-13-203268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/5ff684731bea/aging-13-203268-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/0338be82486d/aging-13-203268-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/4c5b83b1926f/aging-13-203268-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/393f1ae72f22/aging-13-203268-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/8312441/d948ebf9ec72/aging-13-203268-g007.jpg

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