El Falaky I H, Vestergaard B F, Hornsleth A
Scand J Infect Dis. 1977;9(2):79-84. doi: 10.3109/inf.1977.9.issue-2.05.
A total of 112 cases from 12 cases of non-genital herpes simplex, 13 cases of herpes genitalis and 60 selected controls was titrated by the indirect fluorescent antibody method for IgG, IgA and IgM antibodies against herpes simplex virus (HSV) type 1 and type 2. Mean titres of IgA against HSV type 1 were 6-8 times higher in patients with acute and recent non-genital herpes simplex than the mean titres of the controls, while the corresponding mean titres were only slightly elevated in patients with herpes genitalis. In this latter group of patients IgA antibody titres to HSV type 2 were 4 times higher than the control titres. IgM antibody titres were not elevated in patients with non-genital herpes simplex, but in patients with herpes genitalis IgM antibodies to HSV type 2 increased to 4 times the normal values 2-4 weeks after infection. Measurement of serum IgA antibodies to HSV types 1 and 2 might be an important diagnostic tool in acute and recent HSV infections.
采用间接荧光抗体法对12例非生殖器单纯疱疹、13例生殖器疱疹患者以及60例选定对照的总共112份病例进行了针对1型和2型单纯疱疹病毒（HSV）的IgG、IgA和IgM抗体滴定。急性和近期非生殖器单纯疱疹患者中，针对1型HSV的IgA平均滴度比对照的平均滴度高6至8倍，而在生殖器疱疹患者中相应的平均滴度仅略有升高。在后一组患者中，针对2型HSV的IgA抗体滴度比对照滴度高4倍。非生殖器单纯疱疹患者的IgM抗体滴度未升高，但在生殖器疱疹患者中，感染后2至4周，针对2型HSV的IgM抗体增加至正常值的4倍。检测血清中针对1型和2型HSV的IgA抗体可能是急性和近期HSV感染的一项重要诊断工具。
