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Cardiac glycosides and COVID-19: would it be a promising therapeutic approach?

作者信息

Siniorakis Eftychios, Arvanitakis Spyridon, Elkouris Maximilianos

机构信息

Department of Cardiology, Sotiria Chest Diseases Hospital, 152 Mesogeion Avenue, 11527, Athens, Greece.

Department of Clinical Biochemistry, Sotiria Chest Diseases Hospital, 152 Mesogeion Avenue, 11527, Athens, Greece.

出版信息

An Acad Bras Cienc. 2020 Oct 28;92(4):e20201080. doi: 10.1590/0001-3765202020201080. eCollection 2020.

DOI:10.1590/0001-3765202020201080
PMID:33146236
Abstract

Cardiac glycosides have been found to have an anti-viral effect. This was noted in the past during various epidemics including MERS and SARS. It is due to their inhibitory effect on the Na, K-ATPase membrane pump. Furthermore, they exhibit anti-inflammatory properties. These preclinical observations may prove useful in further clinical utility of these well-known compounds in the current COVID-19 pandemic.

摘要

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