Wegmüller E, Frey B, Hodler J
Schweiz Med Wochenschr. 1977 Jul 23;107(29):1028-34.
The complement system may be activated by two pathways, the classical and the alternate. To evaluate their respective participation in different forms of glomerulonephritis, the plasma values of C3, C4, C3PA, C1q and properdin were determined in 70 patients. In systemic lupus erythematosus (LED), acute poststreptococcal glomerulonephritis (AGN) and septicemia the classical pathway appears to be mainly involved, whereas the amplification loop and the alternate pathway seem to be of secondary importance. By contrast, in membranoproliferative glomerulonephritis (MPGN) the alternate pathway plays a major role. However, the present data suggest that activation of the classical pathway may often be involved as well. In minimal change glomerulonephritis no signs indicating involvement of the complement system were apparent. Follow-up observation demonstrated a correlation between decreases in plasma complement concentrations and the clinical severity of the primary disease in LED, AGN and septicemia, but not in MPGN.
补体系统可通过两条途径激活，即经典途径和替代途径。为评估它们在不同类型肾小球肾炎中的各自作用，测定了70例患者的C3、C4、C3PA、C1q和备解素的血浆值。在系统性红斑狼疮（SLE）、急性链球菌感染后肾小球肾炎（AGN）和败血症中，经典途径似乎起主要作用，而放大环和替代途径似乎次要。相比之下，在膜增生性肾小球肾炎（MPGN）中，替代途径起主要作用。然而，目前的数据表明经典途径的激活可能也常参与其中。在微小病变性肾小球肾炎中，未发现补体系统受累的明显迹象。随访观察表明，SLE、AGN和败血症患者血浆补体浓度降低与原发疾病的临床严重程度相关，但MPGN患者并非如此。
