Williams D E, Worley S D, Barnela S B, Swango L J
Department of Chemistry, College of Science and Mathematics, Auburn University, Alabama 36849-3501.
Appl Environ Microbiol. 1987 Sep;53(9):2082-9. doi: 10.1128/aem.53.9.2082-2089.1987.
The bactericidal efficacies of three organic N,N'-dihalamine disinfectants in the class of compounds termed imidazolidinones were determined for combinations of pH, temperature, and water quality treatments by using Staphylococcus aureus and Shigella boydii as test organisms. The compound 1,3-dibromo-4,4,5,5-tetramethyl-2-imidazolidinone was found to be the most rapidly acting bactericide, especially under halogen-demand-free conditions. The mixed N,N'-dihalamine 1-bromo-3-chloro-4,4,5,5-tetramethyl-2-imidazolidinone was found to be intermediate in terms of rate of disinfection, while the compound 1,3-dichloro-4,4,5,5-tetramethyl-2-imidazolidinone was observed to be the slowest acting bactericide. When overall effectiveness was judged on the basis of stability of the disinfectants along with rates of disinfection, the mixed halamine was considered to exhibit great potential for use as a disinfectant in an aqueous solution.
以金黄色葡萄球菌和鲍氏志贺菌为测试菌株，针对pH值、温度和水质处理的组合，测定了咪唑烷酮类化合物中三种有机N,N'-二卤胺消毒剂的杀菌效果。发现化合物1,3-二溴-4,4,5,5-四甲基-2-咪唑烷酮是作用最快的杀菌剂，尤其是在无卤素需求的条件下。混合N,N'-二卤胺1-溴-3-氯-4,4,5,5-四甲基-2-咪唑烷酮在消毒速率方面处于中等水平，而观察到化合物1,3-二氯-4,4,5,5-四甲基-2-咪唑烷酮是作用最慢的杀菌剂。当根据消毒剂的稳定性以及消毒速率来判断总体效果时，混合卤胺被认为在水溶液中用作消毒剂具有很大潜力。
