Choi Yoon-Jung, Moskowitz Joel M, Myung Seung-Kwon, Lee Yi-Ryoung, Hong Yun-Chul
Department of Family Medicine and Center for Cancer Prevention and Detection, Hospital, National Cancer Center, Goyang 10408, Korea.
Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 110-744, Korea.
Int J Environ Res Public Health. 2020 Nov 2;17(21):8079. doi: 10.3390/ijerph17218079.
We investigated whether cellular phone use was associated with increased risk of tumors using a meta-analysis of case-control studies. PubMed and EMBASE were searched from inception to July 2018. The primary outcome was the risk of tumors by cellular phone use, which was measured by pooling each odds ratio (OR) and its 95% confidence interval (CI). In a meta-analysis of 46 case-control studies, compared with never or rarely having used a cellular phone, regular use was not associated with tumor risk in the random-effects meta-analysis. However, in the subgroup meta-analysis by research group, there was a statistically significant positive association (harmful effect) in the Hardell et al. studies (OR, 1.15-95% CI, 1.00 to 1.33- = 10), a statistically significant negative association (beneficial effect) in the INTERPHONE-related studies (case-control studies from 13 countries coordinated by the International Agency for Research on Cancer (IARC); (OR, 0.81-95% CI, 0.75 to 0.89- = 9), and no statistically significant association in other research groups' studies. Further, cellular phone use with cumulative call time more than 1000 h statistically significantly increased the risk of tumors. This comprehensive meta-analysis of case-control studies found evidence that linked cellular phone use to increased tumor risk.
我们通过对病例对照研究进行荟萃分析，调查了使用手机是否会增加患肿瘤的风险。检索了PubMed和EMBASE数据库，时间跨度从建库至2018年7月。主要结局是使用手机导致的患肿瘤风险，通过汇总每个比值比（OR）及其95%置信区间（CI）来衡量。在对46项病例对照研究的荟萃分析中，与从未或很少使用手机相比，在随机效应荟萃分析中，经常使用手机与肿瘤风险无关。然而，在按研究组进行的亚组荟萃分析中，哈德尔等人的研究存在统计学上显著的正相关（有害效应）（OR，1.15 - 95%CI，1.00至1.33 - = 10），国际癌症研究机构（IARC）协调的13个国家的INTERPHONE相关研究（病例对照研究）存在统计学上显著的负相关（有益效应）（OR，0.81 - 95%CI，0.75至0.89 - = 9），其他研究组的研究则无统计学上显著的相关性。此外，累积通话时间超过1000小时的手机使用在统计学上显著增加了患肿瘤的风险。这项对病例对照研究的综合荟萃分析发现了将手机使用与患肿瘤风险增加相关联的证据。
