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辅食添加年龄对1至3岁韩国儿童哮喘和特应性皮炎发病的影响。

Influence of age at complementary food introduction on the development of asthma and atopic dermatitis in Korean children aged 1-3 years.

作者信息

Lee Jihyun, Shin Meeyong, Lee Bora

机构信息

Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University School of Medicine, Bucheon, Korea.

Institute of Health & Environment, Graduate School of Public Health, Seoul National University, Seoul, Korea.

出版信息

Clin Exp Pediatr. 2021 Aug;64(8):408-414. doi: 10.3345/cep.2020.01382. Epub 2020 Nov 1.

Abstract

BACKGROUND

Complementary food in infancy is necessary for human growth, neurodevelopment, and health. However, the role of allergen consumption in early infancy and its effects on the development of food allergy or tolerance remain unclear.

PURPOSE

To investigate the influence of age at the time of complementary food introduction on the development of asthma and atopic dermatitis in Korean children aged 1-3 years.

METHODS

We combined data from the Korea National Health and Nutrition Examination Survey collected from 2010 to 2014 and analyzed 1619 children aged 1-3 years who were included in the survey. Multivariate regression analysis was used to identify associations among type of feeding, age at the time of complementary food introduction, and doctor-diagnosed atopic dermatitis and asthma.

RESULTS

Age at the time of complementary food introduction was not significantly associated with doctor-diagnosed atopic dermatitis and asthma in children aged 1-3 years. In the univariate analysis, children with asthma showed higher water and sodium intake levels than nonasthmatic children. However, this relationship was not significant in the multivariate regression analysis.

CONCLUSION

The present study revealed no statistically significant relationship between age at the time of complementary food introduction and the risk of atopic dermatitis and asthma in young Korean children. A national prospective study is needed to clarify the influence of age at the time of complementary food introduction on the development of allergic diseases.

摘要

背景

婴儿期的辅食对人类生长、神经发育和健康至关重要。然而,婴儿早期食用过敏原的作用及其对食物过敏或耐受发展的影响仍不明确。

目的

研究辅食添加年龄对1至3岁韩国儿童哮喘和特应性皮炎发展的影响。

方法

我们整合了2010年至2014年韩国国家健康与营养检查调查的数据,并分析了该调查中纳入的1619名1至3岁儿童。采用多变量回归分析来确定喂养类型、辅食添加年龄与医生诊断的特应性皮炎和哮喘之间的关联。

结果

辅食添加年龄与1至3岁儿童医生诊断的特应性皮炎和哮喘无显著关联。在单变量分析中,哮喘儿童的水和钠摄入量高于非哮喘儿童。然而,在多变量回归分析中,这种关系并不显著。

结论

本研究表明,韩国幼儿的辅食添加年龄与特应性皮炎和哮喘风险之间无统计学显著关系。需要进行全国性前瞻性研究,以阐明辅食添加年龄对过敏性疾病发展的影响。

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