辅助生殖技术中后代次生性别比的相关因素：中国吉林省的一项横断面研究
Associated factors of secondary sex ratio of offspring in assisted reproductive technology: a cross-sectional study in Jilin Province, China.
作者信息
Wang Mohan, Liu Xiangyin, Zhang Han, Li Leilei, Liu Ruizhi, Zhang Hongguo, Yu Yang
机构信息
Center of Reproductive Medicine, Center of Prenatal Diagnosis, the First Hospital, Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021, China.
出版信息
BMC Pregnancy Childbirth. 2020 Nov 4;20(1):666. doi: 10.1186/s12884-020-03373-1.
BACKGROUND
The aim of this study was to determine the secondary sex ratio (SSR) of offspring in assisted reproduction technology (ART) in Jilin Province, China, and to analyse the influencing factors associated with SSR.
METHODS
A cross-sectional study of 3833 babies including singletons and twins born to 2990 couples treated by ART between May 2011 and December 2018 was performed.
RESULTS
The main outcomes of this study were that the SSR of ART babies in Jilin Province was 50.64% and the SSR was associated with fertilization methods (p < 0.05). Comparing to in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) (OR = 0.808, 95%CI: 0.681-0.958) decreased the percentage of male babies.
CONCLUSIONS
This study suggests that the SSR of ART births in Jilin Province was lower than the normal level and ICSI had a significant effect on SSR. Though we need more samples to study in the future, we still need to think about the impact of ICSI on SSR in ART.
背景
本研究旨在确定中国吉林省辅助生殖技术（ART）中后代的出生性别比（SSR），并分析与SSR相关的影响因素。
方法
对2011年5月至2018年12月期间接受ART治疗的2990对夫妇所生的3833名婴儿（包括单胎和双胞胎）进行横断面研究。
结果
本研究的主要结果是吉林省ART婴儿的SSR为50.64%，且SSR与受精方式有关（p<0.05）。与体外受精（IVF）相比，卵胞浆内单精子注射（ICSI）（OR=0.808，95%CI：0.681-0.958）降低了男婴的比例。
结论
本研究表明吉林省ART出生的SSR低于正常水平，ICSI对SSR有显著影响。尽管未来我们需要更多样本进行研究，但我们仍需思考ICSI对ART中SSR的影响。
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