School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Centre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia.
Syst Rev. 2020 Nov 4;9(1):255. doi: 10.1186/s13643-020-01506-3.
There is limited evidence for the comparative effectiveness of analgesic medicines for adults with low back pain. This systematic review and network meta-analysis aims to determine the analgesic effect, safety, acceptability, effect on function, and relative rank according to analgesic effect, safety, acceptability, and effect on function of a single course of [an] analgesic medicine(s) or combination of these medicines for people with low back pain.
We will include published and unpublished randomised trials written in any language that compare an analgesic medicine to either another medicine, placebo/sham, or no intervention in adults with low back pain, grouped according to pain duration: acute (fewer than 6 weeks), sub-acute (6 to 12 weeks), and chronic (greater than 12 weeks). The co-primary outcomes are pain intensity following treatment and safety (adverse events). The secondary outcomes are function and acceptability (all-cause dropouts). We will perform a network meta-analysis to compare and rank analgesic medicines. We will form judgements of confidence in the results using the Confidence in Network Meta-Analysis (CINeMA) methodology.
This network meta-analysis will establish which medicine, or combination of medicines, is most effective for reducing pain and safest for adults with low back pain.
PROSPERO CRD42019145257.
对于腰痛成人患者，镇痛药物的疗效比较证据有限。本系统评价和网络荟萃分析旨在确定单一疗程[某种]镇痛药物或这些药物组合的镇痛效果、安全性、可接受性、对功能的影响，以及根据镇痛效果、安全性、可接受性和对功能的影响进行相对排序，用于腰痛成人患者。
我们将纳入发表和未发表的、用任何语言书写的随机试验，比较镇痛药物与另一种药物、安慰剂/假治疗或无干预在腰痛成人患者中的疗效，按疼痛持续时间分组：急性（少于 6 周）、亚急性（6 至 12 周）和慢性（超过 12 周）。主要结局是治疗后疼痛强度和安全性（不良事件）。次要结局是功能和可接受性（所有原因的脱落）。我们将进行网络荟萃分析以比较和排序镇痛药物。我们将使用置信网络荟萃分析（CINeMA）方法对结果的置信度进行判断。
这项网络荟萃分析将确定哪种药物或药物组合对减轻腰痛成人的疼痛最有效，且最安全。
PROSPERO CRD42019145257。
