The University of Sydney Brain and Mind Research Institute, Camperdown, New South Wales, Australia
Child and Adolescent Psychiatry, Canberra Hospital, Canberra, Australian Capital Territory, Australia.
BMJ Case Rep. 2020 Nov 3;13(11):e235346. doi: 10.1136/bcr-2020-235346.
The management of challenging and refractory destructive behaviour in young patients with intellectual disability (ID) is a major issue faced by families, carers and healthcare professionals who support them. Often, paediatricians and psychiatrists use various behavioural and psychopharmacological approaches, including polypharmacy. We report on one such patient who benefitted greatly from a trial of clozapine, resulting in less aggression, improved quality of life and potentially huge cost savings. We conclude that clozapine may represent a beneficial though seldom-used option for severe, destructive behaviour in young people with ID.
管理有智力障碍 (ID) 的年轻患者的挑战性和难治性破坏性行为是家庭、护理人员和支持他们的医疗保健专业人员面临的主要问题。儿科医生和精神科医生通常会使用各种行为和精神药理学方法，包括联合用药。我们报告了这样一个受益于氯氮平试验的患者，结果表明他的攻击行为减少，生活质量提高，并且可能节省大量成本。我们的结论是，氯氮平可能是 ID 青少年严重破坏性行为的一种有益但很少使用的选择。
