Trauma & Orthopaedics, Morriston Hospital, Swansea, UK
Trauma & Orthopaedics, Morriston Hospital, Swansea, UK.
BMJ Case Rep. 2020 Nov 3;13(11):e237116. doi: 10.1136/bcr-2020-237116.
A 65-year old man presented with 6-week history of bilateral knee pain and swelling, with difficulty mobilising. He had bilateral total knee arthroplasties in situ performed 5 years prior complicated by postoperative wound infection. Bilateral synovial fluid cultures were positive for , and extensive investigations had not identified an extra-articular source of infection. Failing debridement antibiotic and implant retention procedure, the patient underwent a simultaneous bilateral 2-stage revision with articulated cement spacers impregnated with vancomycin and gentamycin. The patient received 6 weeks of intravenous antibiotics after each stage. is a nutritiously fastidious organism, posing a challenge for clinical laboratories to isolate and perform antimicrobial susceptibility testing, yet prosthetic joint infections caused by are scarce in literature and present atypically with subacute signs of chronic infection. This poses a diagnostic and therapeutic challenge, and two-stage revision is the only documented treatment that successfully eradicates the infection.
一位 65 岁男性,双侧膝关节疼痛和肿胀 6 周,活动困难。他 5 年前曾行双侧全膝关节置换术,术后发生伤口感染。双侧关节滑液培养均为 阳性,广泛的检查未发现关节外感染源。清创、保留抗生素和植入物的治疗方案失败后,患者行双侧 2 期翻修,使用载万古霉素和庆大霉素的关节水泥间隔器。每阶段后患者接受 6 周静脉抗生素治疗。 是一种营养要求苛刻的生物体,给临床实验室带来了分离和进行抗菌药物敏感性测试的挑战,但由 引起的人工关节感染在文献中很少见,表现为亚急性慢性感染的特征。这带来了诊断和治疗方面的挑战,而两期翻修是唯一被证实能成功消除感染的治疗方法。