University of Calgary, VCDS, 2500 University Drive NW, Calgary, Alberta T2N 1N4 (McCrae, Guigand, Léguillette); Washington State University, VCS, PO Box 6610, Pullman, Washington 99164-6610, USA (K.B. Jones, Thueson, Troudt, Warlick, Sides, Bayly); University of California, Surgical & Radiological Sciences, 944 Garrod Drive, Davis, California 95616, USA (J.H. Jones).
Can Vet J. 2020 Nov;61(11):1181-1185.
High pulmonary blood pressure contributes to exercise-induced pulmonary hemorrhage. The objective of this study was to use bioimpedance spectroscopy to assess body fluid compartment volumes under 3 conditions in 6 racehorses: i) Pre- and post-supramaximal treadmill exercise (control); ii) Exercise 4 hours after furosemide (0.5 mg/kg body weight, IV); iii) Exercise, removal of ~14 L of blood and subsequent reinfusion of the blood. Statistical analysis used linear mixed effects models. Body compartment volumes did not change during the control runs. Total body water (TBW) ( = 0.007, = 0.007), extracellular fluid (ECF) ( = 0.003, = 0.003), and intracellular fluid (ICF) volumes ( = 0.04, = 0.04) decreased pre- and post-exercise following furosemide administration. The ICF trended to decrease ( = 0.07) after slow removal of blood. Blood reinfusion increased TBW ( = 0.02, = 0.02) and ICF ( = 0.005, = 0.005) pre- and post-exercise.
高肺血流量可导致运动性肺出血。本研究的目的是使用生物阻抗光谱法评估 6 匹赛马在 3 种情况下的体液腔室体积：i）超最大跑步机运动前和后（对照）；ii）运动后 4 小时给予呋塞米（0.5mg/kg 体重，静脉注射）；iii）运动、去除约 14 升血液和随后回输血液。统计分析采用线性混合效应模型。在对照过程中，身体腔室体积没有变化。总体液量（TBW）（=0.007，=0.007）、细胞外液（ECF）（=0.003，=0.003）和细胞内液（ICF）体积（=0.04，=0.04）在呋塞米给药后运动前和运动后均减少。在缓慢去除血液后，ICF 呈下降趋势（=0.07）。血液回输增加了 TBW（=0.02，=0.02）和运动前后的 ICF（=0.005，=0.005）。
