运动、呋塞米、放血和输血对马体液腔室容量的影响。
Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses.
机构信息
University of Calgary, VCDS, 2500 University Drive NW, Calgary, Alberta T2N 1N4 (McCrae, Guigand, Léguillette); Washington State University, VCS, PO Box 6610, Pullman, Washington 99164-6610, USA (K.B. Jones, Thueson, Troudt, Warlick, Sides, Bayly); University of California, Surgical & Radiological Sciences, 944 Garrod Drive, Davis, California 95616, USA (J.H. Jones).
出版信息
Can Vet J. 2020 Nov;61(11):1181-1185.
High pulmonary blood pressure contributes to exercise-induced pulmonary hemorrhage. The objective of this study was to use bioimpedance spectroscopy to assess body fluid compartment volumes under 3 conditions in 6 racehorses: i) Pre- and post-supramaximal treadmill exercise (control); ii) Exercise 4 hours after furosemide (0.5 mg/kg body weight, IV); iii) Exercise, removal of ~14 L of blood and subsequent reinfusion of the blood. Statistical analysis used linear mixed effects models. Body compartment volumes did not change during the control runs. Total body water (TBW) ( = 0.007, = 0.007), extracellular fluid (ECF) ( = 0.003, = 0.003), and intracellular fluid (ICF) volumes ( = 0.04, = 0.04) decreased pre- and post-exercise following furosemide administration. The ICF trended to decrease ( = 0.07) after slow removal of blood. Blood reinfusion increased TBW ( = 0.02, = 0.02) and ICF ( = 0.005, = 0.005) pre- and post-exercise.
高肺血流量可导致运动性肺出血。本研究的目的是使用生物阻抗光谱法评估 6 匹赛马在 3 种情况下的体液腔室体积：i）超最大跑步机运动前和后（对照）；ii）运动后 4 小时给予呋塞米（0.5mg/kg 体重，静脉注射）；iii）运动、去除约 14 升血液和随后回输血液。统计分析采用线性混合效应模型。在对照过程中，身体腔室体积没有变化。总体液量（TBW）（=0.007，=0.007）、细胞外液（ECF）（=0.003，=0.003）和细胞内液（ICF）体积（=0.04，=0.04）在呋塞米给药后运动前和运动后均减少。在缓慢去除血液后，ICF 呈下降趋势（=0.07）。血液回输增加了 TBW（=0.02，=0.02）和运动前后的 ICF（=0.005，=0.005）。
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