Tong Yao, Xie Xiaoyan, Mao Xiaodan, Lei Huifang, Chen Yaojia, Sun Pengming
Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, People's Republic of China.
Department of Gynecology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, People's Republic of China.
Cancer Manag Res. 2020 Oct 29;12:10849-10859. doi: 10.2147/CMAR.S271078. eCollection 2020.
We investigated the relationship between metabolic syndrome (MetS) and its components and erythrocyte parameters such as red blood cell count (RBC) and hemoglobin (Hb) levels, and their association with the risk of deep myometrial invasion in endometrioid endometrial carcinoma (EEC).
A total of 473 women diagnosed with EEC between January 2012 and December 2018 were included in the study. MetS was diagnosed using a modified version of the Chinese Diabetes Society 2004 criteria. Demographic and clinical characteristics were stratified by MetS and compared. Logistic regression analyses were performed to calculate the odds ratios (ORs) of myometrial invasion.
The prevalence of MetS was 18.8% (89/473). RBC and Hb levels were significantly higher in EEC patients with MetS. RBC and Hb values increased linearly with the number of MetS components. The OR of the MetS risk increased across the RBC quartiles (OR=2.212, 95% confidence interval [Cl]=1.125-4.350, P˂0.05). Among EEC patients with MetS, the OR of deep myometrial invasion increased with the decrease of the RBC quartiles (P=0.037). Similarly, in EEC patients with obesity and hyperglycemia or with ≥2 MetS criteria, the lowest RBC level (Q1) was a risk factor for deep myometrial invasion compared with the reference RBC group (Q4, P˂0.05). However, this trend was not evident in EEC patients without MetS and its components.
EEC with MetS and its components had higher RBC and Hb levels. The association between the erythrocyte parameters and myometrial invasion differed with MetS. RBC was identified as a risk factor of myometrial invasion in EEC patients with MetS and its components.
我们研究了代谢综合征（MetS）及其组分与红细胞参数（如红细胞计数（RBC）和血红蛋白（Hb）水平）之间的关系，以及它们与子宫内膜样腺癌（EEC）肌层深部浸润风险的关联。
本研究纳入了2012年1月至2018年12月期间共473例诊断为EEC的女性。采用中国糖尿病学会2004年标准的修订版诊断MetS。根据MetS对人口统计学和临床特征进行分层并比较。进行逻辑回归分析以计算肌层浸润的比值比（OR）。
MetS的患病率为18.8%（89/473）。患有MetS的EEC患者的RBC和Hb水平显著更高。RBC和Hb值随MetS组分数量呈线性增加。MetS风险的OR在RBC四分位数中呈增加趋势（OR = 2.212，95%置信区间[Cl] = 1.125 - 4.350，P＜0.05）。在患有MetS的EEC患者中，肌层深部浸润的OR随RBC四分位数的降低而增加（P = 0.037）。同样，在患有肥胖症和高血糖症或符合≥2条MetS标准的EEC患者中，与参考RBC组（Q4）相比，最低RBC水平（Q1）是肌层深部浸润的危险因素（P＜0.05）。然而，在没有MetS及其组分的EEC患者中，这种趋势并不明显。
患有MetS及其组分的EEC患者具有更高的RBC和Hb水平。红细胞参数与肌层浸润之间的关联因MetS而异。在患有MetS及其组分的EEC患者中，RBC被确定为肌层浸润的危险因素。
