Zhong Wenhui, Zhou Chunyu, Chen Lufei, Wang Zhenna, Lin Hongxing, Wu Kunhai, Zhang Sujiao
Clinical Laboratory, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.
Nursing Department, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China.
Int J Gen Med. 2021 Sep 21;14:5903-5910. doi: 10.2147/IJGM.S323136. eCollection 2021.
This study assessed the prognostic value of red blood cell distribution width (RDW) and cancer antigen 125 (CA125) in predicting the prognosis of endometrial cancer (EC) patients.
In this study, we included 525 patients with EC between January 2013 and January 2019. Demographic and clinical indicators were collected, and the receiver operating characteristics curve (ROC) and cutoff values were calculated between the early and advanced stages of EC. Independent risk factors associated with EC prognosis were assessed using Cox regression analyses and the Kaplan-Meier method.
Compared to women in the early stage of EC, women with advanced stage had significantly elevated RDW coefficient of variation (RDW-CV) and CA125 levels and lower mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (both P < 0.05). Consequently, RDW-CV and CA125 were found to be independent risk factors for EC by using ROC curve and multivariate logistic regression analysis. The survival analysis curve was used to assess the diagnostic value of RDW-CV, CA125, and their combination in the prognosis of EC. The results showed that patients with high expression of RDW-CV and CA125 had worse overall survival than those with low expression. Moreover, multivariate Cox regression analysis indicated that RDW-CV+CA125=2 was an independent prognostic factor.
These findings suggest that CA125 combined with RDW-CV has a good prognostic value for EC. Thus, the RDW-CV+CA125 score is a promising prognostic marker for the clinical decision-making process regarding EC outcomes.
本研究评估红细胞分布宽度（RDW）和癌抗原125（CA125）在预测子宫内膜癌（EC）患者预后方面的价值。
本研究纳入了2013年1月至2019年1月期间的525例EC患者。收集了人口统计学和临床指标，并计算了EC早期和晚期之间的受试者工作特征曲线（ROC）及临界值。使用Cox回归分析和Kaplan-Meier方法评估与EC预后相关的独立危险因素。
与EC早期的女性相比，晚期女性的RDW变异系数（RDW-CV）和CA125水平显著升高，平均红细胞体积（MCV）和平均红细胞血红蛋白含量（MCH）降低（均P<0.05）。因此，通过ROC曲线和多因素逻辑回归分析发现RDW-CV和CA125是EC的独立危险因素。生存分析曲线用于评估RDW-CV、CA125及其联合检测在EC预后中的诊断价值。结果显示，RDW-CV和CA125高表达的患者总生存期较低表达患者差。此外，多因素Cox回归分析表明RDW-CV+CA125=2是一个独立的预后因素。
这些发现表明，CA125联合RDW-CV对EC具有良好的预后价值。因此，RDW-CV+CA125评分是用于EC预后临床决策过程的一个有前景的预后标志物。
