Skinner Charlotte, Thompson Alex J, Thursz Mark R, Marchesi Julian R, Vergis Nikhil
Department of Metabolism, Digestion and Reproduction, St Mary's Hospital Campus, Imperial College London, London, UK.
Department of Surgery & Cancer, St. Mary's Hospital Campus, Imperial College London, London, UK.
Therap Adv Gastroenterol. 2020 Oct 16;13:1756284820942616. doi: 10.1177/1756284820942616. eCollection 2020.
Increased bacterial translocation (BT) across the gut barrier due to greater intestinal permeability (IP) is seen across a range of conditions, including alcohol-related liver disease (ArLD). The phenomenon of BT may contribute to both the pathogenesis and the development of complications in ArLD. There are a number of methods available to assess IP and in this review we look at their various advantages and limitations. The knowledge around BT and IP in ArLD is also reviewed, as well as the therapeutic strategies currently in use and in development.
在包括酒精性肝病（ArLD）在内的一系列病症中，均可观察到由于肠道通透性（IP）增加导致细菌易位（BT）穿过肠道屏障的现象。BT现象可能在ArLD的发病机制和并发症发展中都起作用。有多种方法可用于评估IP，在本综述中，我们将探讨它们的各种优缺点。同时还将综述有关ArLD中BT和IP的知识，以及目前正在使用和研发的治疗策略。
