Laboratory of Genetics and Molecular Cardiology, InCor-Heart Institute, Medical School, University of São Paulo, São Paulo, BR.
Laboratory of Medical Investigation LIM-37, University of São Paulo, Medical School, São Paulo, BR.
Glob Heart. 2020 Oct 21;15(1):71. doi: 10.5334/gh.873.
Heart rate variability (HRV) is a noninvasive method for assessing autonomic function. Age, sex, and chronic conditions influence HRV.
Our aim was to evaluate HRV measures exploring differences by age, sex, and race in a sample from a rural area.
Analytical sample (n = 1,287) included participants from the 2010 to 2016 evaluation period of the Baependi Heart Study, a family-based cohort in Brazil. Participants underwent 24-hour Holter-ECG (Holter) monitoring. To derive population reference values, we restricted our analysis to a 'healthy' subset (i.e. absence of medical comorbidities). A confirmatory analysis was conducted with a subgroup sample that also had HRV derived from a resting ECG 10'-protocol obtained during the same time period.
The 'healthy' subset included 543 participants. Mean age was 40 ± 14y, 41% were male, 74% self-referred as white and mean body-mass-index was 24 ± 3kg/m. Time domain HRV measures showed significant differences by age-decade and by sex. Higher values were observed for males across almost all age-groups. Parasympathetic associated variables (rMSSD and pNN50) showed a U-shaped distribution and reversal increase above 60y. Sympathetic-parasympathetic balance variables (SDNN, SDANN) decreased linearly by age. Race differences were no significant. We compared time domain variables with complete data (Holter and resting ECG) between 'healthy' versus 'unhealthy' groups. Higher HRV values were shown for the 'healthy' subset compared with the 'unhealthy' group.
HRV measures vary across age and sex. A U-shaped pattern and a reversal increase in parasympathetic variables may reflect an age-related autonomic dysfunction even in healthy individuals that could be used as a predictor of disease development.
心率变异性（HRV）是评估自主神经功能的一种非侵入性方法。年龄、性别和慢性疾病会影响 HRV。
我们旨在评估 HRV 指标，以探索巴西一个农村地区样本中年龄、性别和种族的差异。
分析样本（n=1287）包括 2010 年至 2016 年 Baependi 心脏研究评估期间的参与者，这是巴西的一个基于家庭的队列。参与者接受了 24 小时 Holter-ECG（Holter）监测。为了获得人群参考值，我们将分析仅限于“健康”亚组（即无医疗合并症）。还对同一时期获得的来自静息 ECG 10'协议的 HRV 进行了亚组样本的验证分析。
“健康”亚组包括 543 名参与者。平均年龄为 40±14 岁，41%为男性，74%自报为白人，平均体重指数为 24±3kg/m²。时域 HRV 指标在年龄十年和性别上存在显著差异。在几乎所有年龄段，男性的数值都较高。与年龄相关的迷走神经相关变量（rMSSD 和 pNN50）呈 U 形分布，并在 60 岁以上时呈递增趋势。与年龄相关的交感-迷走神经平衡变量（SDNN、SDANN）呈线性下降。种族差异无显著性。我们比较了“健康”与“不健康”组之间具有完整数据（Holter 和静息 ECG）的时域变量。与“不健康”组相比，“健康”亚组的 HRV 值较高。
HRV 指标随年龄和性别而变化。迷走神经变量的 U 形模式和递增反转可能反映了即使在健康个体中与年龄相关的自主神经功能障碍，这可能可作为疾病发展的预测指标。
