Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
IHRC Inc, Atlanta, GA, USA.
Clin Infect Dis. 2021 Jun 15;72(12):e948-e956. doi: 10.1093/cid/ciaa1680.
We aimed to characterize invasive pneumococcal disease (IPD) isolates collected from multistate surveillance in the United States during 2018 and examine within-serotype propensities of isolates to form related clusters.
We predicted strain features using whole genome sequencing obtained from 2885 IPD isolates obtained through the Center for Disease Control and Prevention's Active Bacterial Core surveillance (ABCs), which has a surveillance population of approximately 34.5 million individuals distributed among 10 states. Phylogenetic analysis was provided for serotypes accounting for ≥27 isolates.
Thirteen-valent pneumococcal conjugate vaccine (PCV13) serotypes together with 6C accounted for 23 of 105 (21.9%) of isolates from children aged <5 years and 820 of 2780 (29.5%) isolates from those aged ≥5 years. The most common serotypes from adult IPD isolates were serotypes 3 (413/2780 [14.9%]), 22F (291/2780 [10.5%]), and 9N (191/2780 [6.9%]). Among child IPD isolates, serotypes 15BC (18/105 [17.1%]), 3 (11/105 [10.5%]), and 33F (10/105 [9.5%]) were most common. Serotypes 4, 12F, 20, and 7F had the highest proportions of isolates that formed related clusters together with the highest proportions of isolates from persons experiencing homelessness (PEH). Among 84 isolates from long-term care facilities, 2 instances of highly related isolate pairs from co-residents were identified.
Non-PCV13 serotypes accounted for >70% of IPD in ABCs; however, PCV13 serotype 3 is the most common IPD serotype overall. Serotypes most common among PEH were more often associated with temporally related clusters identified both among PEH and among persons not reportedly experiencing homelessness.
本研究旨在对美国多州监测期间于 2018 年收集的侵袭性肺炎球菌病（IPD）分离株进行特征描述，并对同型菌株形成相关聚类的倾向进行研究。
我们使用从疾病控制与预防中心（CDC）的主动细菌核心监测（ABCs）中获得的 2885 例 IPD 分离株的全基因组测序来预测菌株特征，该监测系统的监测人群约为 3450 万人，分布在 10 个州。对血清型占比≥27 例的分离株进行了系统发育分析。
十三价肺炎球菌结合疫苗（PCV13）血清型加上 6C 型占<5 岁儿童患者中 105 例分离株的 23 例（21.9%）和≥5 岁儿童患者中 2780 例分离株的 820 例（29.5%）。成人 IPD 分离株中最常见的血清型为 3 型（413/2780 [14.9%]）、22F 型（291/2780 [10.5%]）和 9N 型（191/2780 [6.9%]）。儿童 IPD 分离株中最常见的血清型为 15BC 型（18/105 [17.1%]）、3 型（11/105 [10.5%]）和 33F 型（10/105 [9.5%]）。血清型 4、12F、20 和 7F 型的相关聚类分离株比例最高，与无家可归者（PEH）的分离株比例最高。在来自长期护理机构的 84 株分离株中，发现了 2 例同住者高度相关的分离株对。
非 PCV13 血清型占 ABCs 中 IPD 的比例>70%；然而，PCV13 血清型 3 是总体上最常见的 IPD 血清型。在 PEH 中最常见的血清型与在 PEH 和非无家可归者中发现的时间相关聚类更为常见。
