Khalafi Mousa, Alamdari Karim Azali, Symonds Michael E, Nobari Hadi, Carlos-Vivas Jorge
Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, 4199613776, Iran.
Department of Sport Sciences, Azarbaijan Shahid Madani University, Tabriz, 5375171379, Iran.
Hormones (Athens). 2021 Mar;20(1):23-33. doi: 10.1007/s42000-020-00245-3. Epub 2020 Nov 5.
PURPOSE/OBJECTIVE: The aim of this study was to quantify circulating fibroblast growth factor 21 (FGF-21) changes during and immediately after acute exercise and, based on body weight, to identify the subgroups exhibiting the largest response.
The PubMed, Web of Science, and Cochrane Library electronic databases were searched up to December 2019 for studies published in English peer-reviewed journals. Studies that evaluated the effects of acute exercise on FGF-21 concentrations immediately after and 1 and 3 h post-exercise in adults were included. Random effects models were used for analyses, with data reported as standardized mean difference (SMD) and 95% confidence interval, and the risk of heterogeneity was evaluated. Subgroup analysis of subjects with normal weight and obesity/overweight was performed.
A total of seven studies involving 125 participants (age 35.95 (21-64) years and BMI 25.89 (21.30-35.46) kg/m) were included. Overall, acute exercise increased FGF-21 (d = 0.18; 95% CI 0.01 to 0.35, p = 0.02) and this remained for 1 h post-exercise FGF-21 (d = 0.59; 95% CI 0.33 to 0.86, p = 0.001). Three hours after exercise, FGF-21 was restored to near baseline values (d = - 0.05; 95% CI - 0.34 to 0.22, p = 0.68). Acute exercise raised FGF-21 concentrations in normal weight participants (d = 0.57, p = 0.001) and tended to increase in overweight and obese participants (d = 0.79, p = 0.05) 1 h post-exercise.
Acute exercise increases circulating FGF-21, irrespective of body weight.
目的/目标：本研究的目的是量化急性运动期间及运动后即刻循环成纤维细胞生长因子21（FGF - 21）的变化，并根据体重确定表现出最大反应的亚组。
检索截至2019年12月发表在英文同行评审期刊上的研究，检索了PubMed、科学网和考克兰图书馆电子数据库。纳入评估急性运动对成年人运动后即刻、运动后1小时和3小时FGF - 21浓度影响的研究。采用随机效应模型进行分析，数据以标准化均值差（SMD）和95%置信区间报告，并评估异质性风险。对体重正常和肥胖/超重的受试者进行亚组分析。
共纳入7项研究，涉及125名参与者（年龄35.95（21 - 64）岁，体重指数25.89（21.30 - 35.46）kg/m²）。总体而言，急性运动使FGF - 21升高（d = 0.18；95%置信区间0.01至0.35，p = 0.02），且运动后1小时FGF - 21仍保持升高（d = 0.59；95%置信区间0.33至0.86，p = 0.001）。运动3小时后，FGF - 21恢复至接近基线值（d = - 0.05；95%置信区间 - 0.34至0.22，p = 0.68）。急性运动使体重正常的参与者运动后1小时FGF - 21浓度升高（d = 0.57，p = 0.001），超重和肥胖参与者FGF - 21浓度有升高趋势（d = 0.79，p = 0.05）。
无论体重如何，急性运动均会使循环FGF - 21升高。
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