He Zihong, Tian Ye, Valenzuela Pedro L, Huang Chuanye, Zhao Jiexiu, Hong Ping, He Zilin, Yin Shuhui, Lucia Alejandro
Biology Center, China Institute of Sport Science, Beijing, China.
Culture Development Center, General Administration of Sport of China, Beijing, China.
Front Physiol. 2019 May 29;10:691. doi: 10.3389/fphys.2019.00691. eCollection 2019.
Exercise health benefits are partly mediated by exertional changes in several myokines/adipokines. This study aimed to compare the acute response of some of these biomarkers to aerobic exercise performed at the intensity corresponding to the maximum fat oxidation rate (FATmax) or the "anaerobic" threshold (AT).
Following a cross-over, counterbalanced design, 14 healthy untrained men (23 ± 1 years) performed a 45-min exercise bout at their FATmax or AT intensity (been previously determined through incremental exercise tests). The concentration of interleukin (IL)-15, follistatin, myostatin, fibroblast-growth factor (FGF)-21, irisin, resistin, and omentin was measured at baseline and 0, 1, 3, 24, 48, and 72 h post-exercise.
AT exercise was performed at a higher intensity (85 ± 8 vs. 52 ± 14% of maximal oxygen uptake [VO], < 0.001) and induced a higher energy expenditure ( < 0.001) than FATmax, whereas a greater fat oxidation was observed in the latter ( < 0.001). A higher peak response of FGF-21 (+90%, < 0.01) and follistatin (+49%, < 0.05) was found after AT-exercise, as well as a trend toward a higher peak level of omentin (+13%, = 0.071) and a greater decrease in resistin (-16%, = 0.073).
Increasing exercise load (from FATmax to AT) results in a higher response of FGF-21, follistatin and omentin to aerobic exercise, with the subsequent potential cardiometabolic benefits. No effects were, however, observed on the remainder of biomarkers. Future research should address if manipulating other exercise variables (e.g., type, frequency) can promote a higher myokine/adipokine response.
运动对健康的益处部分是由多种肌动蛋白/脂肪因子的运动性变化介导的。本研究旨在比较其中一些生物标志物对以最大脂肪氧化率（FATmax）或“无氧”阈值（AT）对应的强度进行的有氧运动的急性反应。
采用交叉、平衡设计，14名健康的未经训练的男性（23±1岁）以其FATmax或AT强度进行了45分钟的运动 bout（先前通过递增运动试验确定）。在基线以及运动后0、1、3、24、48和72小时测量白细胞介素（IL）-15、卵泡抑素、肌肉生长抑制素、成纤维细胞生长因子（FGF）-21、鸢尾素、抵抗素和网膜素的浓度。
与FATmax相比，AT运动的强度更高（最大摄氧量[VO]的85±8%对52±14%，P<0.001）且能量消耗更高（P<0.001），而后者的脂肪氧化更高（P<0.001）。AT运动后发现FGF-21（+90%，P<0.01）和卵泡抑素（+49%，P<0.05）的峰值反应更高，以及网膜素峰值水平有升高趋势（+13%，P = 0.071）和抵抗素下降幅度更大（-16%，P = 0.073）。
增加运动负荷（从FATmax到AT）会导致FGF-21、卵泡抑素和网膜素对有氧运动的反应更高，随后可能带来心脏代谢益处。然而，未观察到对其余生物标志物有影响。未来的研究应探讨操纵其他运动变量（如类型、频率）是否能促进更高的肌动蛋白/脂肪因子反应。
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