Ackerman S H, Shindledecker R D
Department of Psychiatry, Cornell University Medical College, White Plains, NY.
Chronobiol Int. 1987;4(1):3-9. doi: 10.1080/07420528709078503.
The available literature on chronobiologic factors in experimental stress ulcer is extremely small and thematically limited. It focuses almost exclusively on circadian rhythms and, within that, on rhythms related to light-dark cycles, activity and body temperature. Among these, only differences in ulcer induction related to circadian activity patterns have been adequately demonstrated. Other circadian patterns and other temporal phase relationships might be profitably explored, including those related to postnatal development. It is also likely that the important relationships between biorhythms and stress ulcer are not limited to ulcer induction. Future studies should address chronobiologic factors in predisposition, severity of illness, the probability of recovery and response to various therapeutic interventions.
关于实验性应激性溃疡中生物钟因素的现有文献极少，且主题有限。它几乎完全集中在昼夜节律上，在昼夜节律中又几乎只关注与明暗周期、活动和体温相关的节律。其中，只有与昼夜活动模式相关的溃疡诱导差异得到了充分证明。其他昼夜模式和其他时间相位关系可能值得探索，包括与出生后发育相关的那些。生物节律与应激性溃疡之间的重要关系也可能不限于溃疡诱导。未来的研究应探讨生物钟因素在易感性、疾病严重程度、康复可能性以及对各种治疗干预的反应中的作用。
