Pearson A D, Mills S, Amineddine H A, Long D R, Craft A W, Chessells J M
Department of Child Health, University of Newcastle upon Tyne, England.
Cancer Chemother Pharmacol. 1987;20(3):243-7. doi: 10.1007/BF00570494.
Repeated methotrexate absorption studies were performed under standard conditions in 127 children receiving either oral or intramuscular methotrexate for acute lymphoblastic leukaemia. There was marked variability in peak concentration, area under the serum concentration curve and clearance both between patients and in repeated studies on the same patient. Although the intramuscular route produced higher serum concentrations and AUC than the oral route, variability within and between patients was considerable and was most marked at higher concentrations. Neither age or sex could account for variation in methotrexate absorption or clearance. Intramuscular methotrexate, although producing higher serum concentrations and AUC, does not reduce the variability observed with oral administration. Prediction of subsequent methotrexate concentrations from the knowledge of one absorption profile is not possible.
在标准条件下，对127名接受口服或肌肉注射甲氨蝶呤治疗急性淋巴细胞白血病的儿童进行了重复的甲氨蝶呤吸收研究。无论是在患者之间还是对同一患者的重复研究中，峰值浓度、血清浓度曲线下面积和清除率都存在显著差异。尽管肌肉注射途径产生的血清浓度和AUC高于口服途径，但患者内部和患者之间的变异性相当大，且在较高浓度时最为明显。年龄和性别均不能解释甲氨蝶呤吸收或清除的差异。肌肉注射甲氨蝶呤虽然产生较高的血清浓度和AUC，但并未降低口服给药时观察到的变异性。根据一次吸收情况预测后续甲氨蝶呤浓度是不可能的。
