Çağlayan Zeynep, Demircan Yalçın Yağmur, Külah Haluk
Department of Electrical and Electronics Engineering, Middle East Technical University, Ankara 06800, Turkey.
METU MEMS Research and Application Center, Ankara 06800, Turkey.
Micromachines (Basel). 2020 Nov 3;11(11):990. doi: 10.3390/mi11110990.
BioMEMS, the biological and biomedical applications of micro-electro-mechanical systems (MEMS), has attracted considerable attention in recent years and has found widespread applications in disease detection, advanced diagnosis, therapy, drug delivery, implantable devices, and tissue engineering. One of the most essential and leading goals of the BioMEMS and biosensor technologies is to develop point-of-care (POC) testing systems to perform rapid prognostic or diagnostic tests at a patient site with high accuracy. Manipulation of particles in the analyte of interest is a vital task for POC and biosensor platforms. Dielectrophoresis (DEP), the induced movement of particles in a non-uniform electrical field due to polarization effects, is an accurate, fast, low-cost, and marker-free manipulation technique. It has been indicated as a promising method to characterize, isolate, transport, and trap various particles. The aim of this review is to provide fundamental theory and principles of DEP technique, to explain its importance for the BioMEMS and biosensor fields with detailed references to readers, and to identify and exemplify the application areas in biosensors and POC devices. Finally, the challenges faced in DEP-based systems and the future prospects are discussed.
生物微机电系统（BioMEMS），即微机电系统（MEMS）在生物和生物医学领域的应用，近年来受到了广泛关注，并在疾病检测、先进诊断、治疗、药物递送、可植入设备和组织工程等方面得到了广泛应用。生物微机电系统和生物传感器技术最重要的主要目标之一是开发即时检测（POC）系统，以便在患者现场进行快速、准确的预后或诊断测试。在感兴趣的分析物中对颗粒进行操控对于POC和生物传感器平台来说是一项至关重要的任务。介电电泳（DEP），即由于极化效应在非均匀电场中引起的颗粒运动，是一种准确、快速、低成本且无需标记的操控技术。它已被视为一种用于表征、分离、运输和捕获各种颗粒的有前景的方法。本综述的目的是提供DEP技术的基本理论和原理，向读者详细引用文献解释其在生物微机电系统和生物传感器领域的重要性，并识别和举例说明其在生物传感器和POC设备中的应用领域。最后，讨论了基于DEP的系统所面临的挑战以及未来前景。
