2nd Department of Ophthalmology, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.
2nd Department of Psychiatry, Aristotle University of Thessaloniki, Psychiatric Hospital of Thessaloniki, Thessaloniki, Greece.
Eur J Ophthalmol. 2022 Jan;32(1):497-500. doi: 10.1177/1120672120968763. Epub 2020 Nov 5.
Central serous chorioretinopathy (CSC) is a disease of the retina that is a frequent cause of mild to moderate visual impairment. The disease can be precipitated by psychosocial stress and hypercortisolism while full remission will often be spontaneous within a few months. Risk factors have included male gender, increased plasma cortisol due to other conditions or steroid use and Type A behavior.
This is a cross-sectional study comparing three research groups that included 100 CSC patients, 200 healthy volunteers, and 200 patients with other ophthalmic disease on their results in the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ).
CSC patients differed from the other subjects on increased high Neuroticism-Anxiety, low Sociability, and high Aggression-Hostility.
Since high Neuroticism is related to increased cortisol levels only in males, and high Aggression-Hostility is related to increased cortisol response, these findings point to the possibility of a robust neurobiological background to the etiopathogenesis of CSC that merits further research. The association of Type A behavior with CSC may be a spurious one and its widespread reference in ophthalmology texts should be re-examined.
中心性浆液性脉络膜视网膜病变（CSC）是一种视网膜疾病，是导致轻度至中度视力损害的常见原因。这种疾病可能由心理社会压力和皮质醇过多引起，而在几个月内通常会自发完全缓解。危险因素包括男性、因其他情况或类固醇使用导致的血浆皮质醇增加，以及 A 型行为。
这是一项横断面研究，比较了三组研究对象，包括 100 名 CSC 患者、200 名健康志愿者和 200 名患有其他眼部疾病的患者，比较他们在 Zuckerman-Kuhlman 人格问卷（ZKPQ）中的结果。
CSC 患者在高神经质-焦虑、低社交性和高攻击性-敌意方面与其他受试者不同。
由于高神经质仅与男性的皮质醇水平升高有关，而高攻击性与皮质醇反应升高有关，这些发现表明 CSC 的发病机制可能存在强大的神经生物学背景，值得进一步研究。A型行为与 CSC 的关联可能是虚假的，其在眼科文献中的广泛引用应重新审查。
