Tello-Cajiao María Elena, Agudelo Olga Lucia, Quintero Marcela, Cardenas Laura, Rosso Fernando
Centro de Investigaciones Clínicas (CIC), Fundación Valle del Lili, Cali, Valle del Cauca, Colombia.
Blood Bank, Fundación Valle del Lili, Cali, Valle del Cauca, Colombia.
Epidemiol Infect. 2020 Nov 6;148:1-25. doi: 10.1017/S0950268820002721.
The prevalence of Chagas disease has decreased in the Americas region due to vector control measures. However, non-vectorial transmission through blood transfusions and organ transplantation has gained importance in recent years. Screening among blood and organ donors are essential to reduce transmission and could provide information to estimate population prevalence. We conducted a cross-sectional study on the prevalence of immunoglobulin G (IgG) antibodies against in healthy blood donors, solid organ donors and heart transplant recipients from 2012 to 2019. We found a total of 99 357 IgG results during the study period. The cumulative seroprevalence in healthy blood donors was 0.13% (95% confidence interval (CI) 0.10–0.15), in organ donors was 0.53% (95% CI 0.06–1.92) and in heart transplant recipients was 3.03 (95% CI 0.07–15.75). Seroprevalence trend in healthy blood donors showed annual increase between 2012 and 2015, decreasing in the following years. No trend was seen in organ donors neither heart recipients. Adjusted rates did not show difference by sex and age among blood donors. No significant increases in seroprevalence were found during the study period. transmission remains low.
由于采取了病媒控制措施，美洲地区恰加斯病的流行率有所下降。然而，近年来通过输血和器官移植的非病媒传播变得越来越重要。对血液和器官捐献者进行筛查对于减少传播至关重要，并且可以提供信息来估计人群流行率。我们对2012年至2019年期间健康献血者、实体器官捐献者和心脏移植受者中抗[此处原文缺失具体病原体]免疫球蛋白G（IgG）抗体的流行率进行了一项横断面研究。在研究期间，我们共获得了99357份IgG检测结果。健康献血者的累积血清阳性率为0.13%（95%置信区间（CI）0.10 - 0.15），器官捐献者为0.53%（95% CI 0.06 - 1.92），心脏移植受者为3.03（95% CI 0.07 - 15.75）。健康献血者的血清阳性率趋势在2012年至2015年期间呈年度上升，随后几年下降。在器官捐献者和心脏移植受者中未发现趋势。调整后的比率在献血者中未显示出性别和年龄差异。在研究期间未发现血清阳性率有显著增加。[此处原文缺失具体病原体]传播仍然很低。
