Miranda Diego Lopes Paim, Ribeiro Gilmar, Lanza Fernanda Cardoso, Santos Fred Luciano Neves, Reis Renato Barbosa, Fraga Deborah Bittencourt Mothé, Silva Luciano Kalabric, Silva Neto Marinho Marques da, Santana Iraildes de Jesus, Reis Mitermayer Galvão Dos
Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brasil.
Laboratório de Patologia e Biologia Molecular, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brasil.
Rev Soc Bras Med Trop. 2019 Aug 1;52:e20190146. doi: 10.1590/0037-8682-0146-2019.
Chagas disease (CD) affects 5.7-7.0 million individuals worldwide, and its prevalence reached 25.1% in the state of Bahia, Brazil. There is an association between the prevalence of CD, the socioeconomic status of the population, and the risk of re-emergence due to non-vectorial transmission, such as blood transfusion. This study determined the seroprevalence of T. cruzi infection among blood donors in the state of Bahia, located in northeastern Brazil, and their epidemiological profile during a 10-year period.
We performed a descriptive cross-sectional study involving a database review. Data were collected from patients with non-negative results for T. cruzi infection during a 10-year period.
A total of 3,084 (0.62%) samples were non-negative for T. cruzi infection in an initial serological screening, and 810 (0.16%) samples were non-negative in the second screening. The correlation between infection and age (30 years or older) and between infection and lower educational level (12 years or less) in the first and second screening was statistically significant. The seroprevalence of T. cruzi infection was higher in men in the first screening. In addition, 99.52% of the municipalities of Bahia had at least one case of CD. Livramento de Nossa Senhora and Salvador presented the highest disease prevalence and recurrence, respectively.
The seroprevalence of T. cruzi infection in these populations was lower than that found in other studies in Brazil but was comparatively higher in densely-populated areas. The demographic characteristics of our population agreed with previous studies.
恰加斯病（CD）在全球影响着570万至700万人，在巴西巴伊亚州其患病率达25.1%。恰加斯病的患病率、人群社会经济状况以及因输血等非媒介传播导致疾病再次出现的风险之间存在关联。本研究确定了位于巴西东北部的巴伊亚州献血者中克氏锥虫感染的血清阳性率及其10年间的流行病学特征。
我们开展了一项描述性横断面研究，涉及数据库回顾。数据收集自10年间克氏锥虫感染检测结果为非阴性的患者。
在初次血清学筛查中，共有3084份样本（0.62%）克氏锥虫感染检测为非阴性，第二次筛查中有810份样本（0.16%）为非阴性。在初次和第二次筛查中，感染与年龄（30岁及以上）以及感染与较低教育水平（12年及以下）之间的相关性具有统计学意义。初次筛查中男性的克氏锥虫感染血清阳性率更高。此外，巴伊亚州99.52%的市至少有1例恰加斯病病例。利夫拉门托 - 德诺萨 - 塞纳拉和萨尔瓦多分别呈现出最高的疾病患病率和复发率。
这些人群中克氏锥虫感染的血清阳性率低于巴西其他研究中的结果，但在人口密集地区相对较高。我们研究人群的人口统计学特征与先前研究一致。
