Agarwal Neeraj, Biswas Bijit, Lohani Pallavi
Department of Community and Family Medicine, All India Institute of Medical Sciences, Patna, Bihar, India.
Niger Postgrad Med J. 2020 Oct-Dec;27(4):293-301. doi: 10.4103/npmj.npmj_301_20.
The study was designed to explore epidemiological characteristics, determinants of COVID-19 infection development and mortality of patients presenting with severe acute respiratory illness (SARI) to a tertiary care health facility of Bihar.
This was an observational record-based study, longitudinal in design. Data of 281 SARI patients who have attended All India Institute of Medical Sciences, Patna, Bihar, India during 25 April 2020, till 12 July 2020 (16 weeks) were used for the study.
Out of 281 study participants, 95 (33.8%) were detected to have COVID-19 and 42 (14.9%) died. Among COVID-positive study subject's death rate was 28.4%. In the multivariable logistic regression analysis; increasing age (adjusted odds ratio [AOR] = 1.02 [1.00-1.03]), gender (males) (AOR = 2.51 [1.27-4.96]), presenting symptom (cough) (AOR = 2.88 [1.46-5.70]), co-morbidity (hypothyroidism) (AOR = 4.59 [1.45-14.56]) and delay between symptom onset and admission (>2 days) (AOR = 2.46 [1.19-5.07]) were significant predictors of COVID-19 infection among study participants adjusted with other co-morbidities (diabetes and hypertension). Similarly, place of residence (outside Patna district) (AOR = 2.38 [1.03-5.50]), co-morbidity (diabetes) (AOR = 3.08 [1.12-8.50]), intensive care unit (ICU) requirement at admission (yes) (AOR = 9.47 [3.98-22.52]) and COVID status (positive) (AOR = 6.33 [2.68-14.96]) were significant predictors of death among the study participants whereas place of residence (outside Patna district) (AOR = 4.04 [1.33-12.28]) and ICU requirement at admission (yes) (AOR = 7.22 [2.54-20.52]) were attributes affecting death of COVID-positive study participants.
Risk of COVID-19 infection among the study participants was high. Age, gender and co-morbidities increased the risk of infection. COVID-19 infection negatively impacted the treatment outcome of the study participants. Age, co-morbidity and ICU requirement were the other attributes affecting mortality.
本研究旨在探讨比哈尔邦一家三级医疗保健机构中出现严重急性呼吸疾病（SARI）的患者的新冠病毒病（COVID-19）感染的流行病学特征、感染发展的决定因素及死亡率。
这是一项基于观察记录的纵向研究。研究使用了2020年4月25日至2020年7月12日（16周）期间在印度比哈尔邦巴特那全印度医学科学研究所就诊的281例SARI患者的数据。
在281名研究参与者中，95例（33.8%）被检测出感染了COVID-19，42例（14.9%）死亡。COVID-19阳性研究对象的死亡率为28.4%。在多变量逻辑回归分析中；年龄增加（调整优势比[AOR]=1.02[1.00-1.03]）、性别（男性）（AOR=2.51[1.27-4.96]）、出现的症状（咳嗽）（AOR=2.88[1.46-5.70]）、合并症（甲状腺功能减退）（AOR=4.59[1.45-14.56]）以及症状出现与入院之间的延迟（>2天）（AOR=2.46[1.19-5.07]）是在对其他合并症（糖尿病和高血压）进行调整后的研究参与者中COVID-19感染的显著预测因素。同样，居住地点（巴特那区以外）（AOR=2.38[1.03-5.50]）、合并症（糖尿病）（AOR=3.08[1.12-8.50]）、入院时需要重症监护病房（ICU）（是）（AOR=9.47[3.98-22.52]）以及COVID状态（阳性）（AOR=6.33[2.68-14.96]）是研究参与者中死亡的显著预测因素，而居住地点（巴特那区以外）（AOR=4.04[1.33-12.28]）和入院时需要ICU（是）（AOR=7.22[2.54-20.52]）是影响COVID-19阳性研究参与者死亡的因素。
研究参与者中COVID-19感染风险很高。年龄、性别和合并症增加了感染风险。COVID-19感染对研究参与者的治疗结果产生了负面影响。年龄合并症和ICU需求是影响死亡率的其他因素。
