Hong Ki-Hong, Lee Young
Department of Family Medicine, Nursing Hospital, Seoul Veterans Hospital, Seoul 05368, Republic of Korea.
Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of Korea.
J Inflamm Res. 2020 Oct 29;13:799-811. doi: 10.2147/JIR.S265856. eCollection 2020.
Vitamins exert its effect through different isoforms. The isoform conversion phases involved are affected outside factors. Here, we investigated the correlation between serum retinol, α-tocopherol, and serum inflammatory markers using stratified data acquired from 2016 to 2018 Korea National Health and Nutrition Examination Survey (KNHANES).
This study was based on data acquired from the 7th edition (2016-2018) of the Korea National Health and Nutrition Examination Survey, consisting of survey data on smoking and alcohol drinking, serum retinol level, serum α-tocopherol level, high-sensitivity C-reactive protein (hs-CRP), and baseline characteristics.
There was a negative correlation between serum retinol and hs-CRP in alcohol drinking men. There was a negative correlation between serum retinol and hs-CRP in the alcohol-nonsmoking female group. There was a positive correlation between α-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking group. There was a positive correlation between α-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking female group. There was positive correlation between vitamin A and E and metabolic syndrome. The lowest vitamin A level was observed in subjects with all five metabolic syndrome criteria matched.
There was a negative correlation between serum retinol and hs-CRP and positive correlation between α-tocopherol and hs-CRP. Absorption and secretion of serum retinol are affected by inflammation status through retinol-binding protein. Alcohol acts as a competitive inhibitor of vitamin A oxidation through alcohol dehydrogenase and ALDH activity. Smoking causes inflammation and induces reactive oxygen species scavenging system and increases cytochrome p450 levels. These factors may have contributed to the observed findings. Metabolic syndrome subjects increased as the levels of vitamin A and vitamin E increased. Since obesity is inversely related to ALDH activity, we postulate that patients with metabolic syndrome may also have low ALDH activity, especially in the Asian population. Future studies are warranted to study the efficacy of ALDH or ALDH inducers in patients with vitamin A deficiency or metabolic syndrome.
维生素通过不同的异构体发挥作用。所涉及的异构体转化阶段会受到外部因素的影响。在此，我们利用2016年至2018年韩国国民健康与营养检查调查（KNHANES）获取的分层数据，研究血清视黄醇、α-生育酚与血清炎症标志物之间的相关性。
本研究基于韩国国民健康与营养检查调查第7版（2016 - 2018年）获取的数据，包括吸烟和饮酒调查数据、血清视黄醇水平、血清α-生育酚水平、高敏C反应蛋白（hs-CRP）以及基线特征。
在饮酒男性中，血清视黄醇与hs-CRP呈负相关。在不饮酒的女性组中，血清视黄醇与hs-CRP呈负相关。在不吸烟且饮酒的组中，α-生育酚与hs-CRP呈正相关。在不吸烟且饮酒的女性组中，α-生育酚与hs-CRP呈正相关。维生素A和E与代谢综合征呈正相关。在符合所有五项代谢综合征标准的受试者中观察到最低的维生素A水平。
血清视黄醇与hs-CRP呈负相关，α-生育酚与hs-CRP呈正相关。血清视黄醇的吸收和分泌受视黄醇结合蛋白的炎症状态影响。酒精通过乙醇脱氢酶和乙醛脱氢酶活性作为维生素A氧化的竞争性抑制剂。吸烟会引发炎症并诱导活性氧清除系统，增加细胞色素p450水平。这些因素可能导致了观察到的结果。随着维生素A和维生素E水平的升高，代谢综合征受试者增加。由于肥胖与乙醛脱氢酶活性呈负相关，我们推测代谢综合征患者也可能具有低乙醛脱氢酶活性，尤其是在亚洲人群中。未来有必要开展研究，以探讨乙醛脱氢酶或其诱导剂对维生素A缺乏或代谢综合征患者的疗效。
