Swartz Justin E, Wegner Inge, Noorlag Rob, van Kempen Pauline M W, van Es Robert J J, de Bree Remco, Willems Stefan M W
Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Center Utrecht, Utrecht, Netherlands.
Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.
Head Neck. 2021 Mar;43(3):745-756. doi: 10.1002/hed.26530. Epub 2020 Nov 5.
Hypoxia is a negative prognostic factor in head and neck squamous cell carcinomas. Under hypoxia, the hypoxia-inducible factor (HIF)-1a transcription factor is overexpressed. We investigated whether there were site differences in HIF-1a expression and its effect on patient outcomes per subsite.
DESIGN/METHOD: A total of 941 patients with HNSCC in the squamous cell carcinoma of the oropharynx (OPSCC, n = 302), oral cavity (OSCC, n = 391), or larynx (LSCC, n = 248) were included. Expression of HIF-1a in tissue samples was investigated using immunohistochemistry. Overall survival (OS), disease-free survival (DFS), and locoregional control (LRC) were analyzed.
HIF-1a expression was higher in OSCC than in LSCC and OPSCC. High HIF-1a expression led to worse prognosis in OPSCC (OS P = .029, DFS P = .085) and LSCC (OS P = .041, DFS P = .011) and better in OSCC (OS P = .055, DFS P = .012). There was no association between HIF-1a and LRC.
High HIF-1a expression is related to poor outcome in OPSCC and LSCC and better outcome in OSCC.
缺氧是头颈部鳞状细胞癌的一个负面预后因素。在缺氧状态下，缺氧诱导因子（HIF）-1α转录因子会过度表达。我们研究了HIF-1α表达是否存在部位差异及其对每个亚部位患者预后的影响。
设计/方法：共纳入941名头颈部鳞状细胞癌患者，其中口咽鳞状细胞癌（OPSCC，n = 302）、口腔鳞状细胞癌（OSCC，n = 391）或喉鳞状细胞癌（LSCC，n = 248）。采用免疫组织化学法研究组织样本中HIF-1α的表达情况。分析总生存期（OS）、无病生存期（DFS）和局部区域控制率（LRC）。
OSCC中HIF-1α的表达高于LSCC和OPSCC。HIF-1α高表达导致OPSCC（OS P = 0.029，DFS P = 0.085）和LSCC（OS P = 0.041，DFS P = 0.011）的预后较差，而在OSCC中预后较好（OS P = 0.055，DFS P = 0.012）。HIF-1α与LRC之间无关联。
HIF-1α高表达与OPSCC和LSCC的不良预后相关，而与OSCC的较好预后相关。
