Dumrongwongsiri Oraporn, Winichagoon Pattanee, Chongviriyaphan Nalinee, Suthutvoravut Umaporn, Grote Veit, Koletzko Berthold
Center for International Health, Lugwig-Maximilians-Universitaet Munich, Munich, Germany.
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
JMIR Res Protoc. 2020 Nov 6;9(11):e19119. doi: 10.2196/19119.
Zinc and iron deficiencies among breastfed infants during the first 6 months of life have been reported in previous studies. The amounts of zinc and iron intakes from breast milk are factors that contribute to the zinc and iron status of breastfed infants.
This study aims to quantitatively determine zinc and iron intakes by breastfed infants during the first 4 months of life and to investigate the factors that predict zinc and iron status in breastfed infants.
Pregnant women at 28 to 34 weeks of gestation were enrolled. Zinc and iron status during pregnancy was assessed. At delivery, cord blood was analyzed for zinc and iron levels. Participants and their babies were followed at 2 and 4 months postpartum. Maternal dietary intakes and anthropometric measurements were performed. The amount of breast milk intake was assessed using the deuterium oxide dose-to-mother technique. Breast milk samples were collected for determination of zinc and iron levels. The amount of zinc and iron consumed by infants was calculated. Zinc and iron status was determined in mothers and infants at 4 months postpartum.
A total of 120 pregnant women were enrolled, and 80 mother-infant pairs completed the study (56 provided full breastfeeding, and 24 provided breast milk with infant formula). All data are being managed and cleaned. Statistical analysis will be done.
This study will provide information on zinc and iron intakes in exclusively breastfed infants during the first 4 months of life and explore predictive factors and the possible association of zinc and iron intakes with infant growth and nutrient status.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/19119.
以往研究报道了6个月龄以内母乳喂养婴儿存在锌和铁缺乏的情况。母乳中的锌和铁摄入量是影响母乳喂养婴儿锌和铁营养状况的因素。
本研究旨在定量测定出生后前4个月母乳喂养婴儿的锌和铁摄入量，并调查预测母乳喂养婴儿锌和铁营养状况的因素。
纳入妊娠28至34周的孕妇，评估孕期锌和铁营养状况。分娩时，分析脐血中的锌和铁水平。产后2个月和4个月对参与者及其婴儿进行随访，测量母亲的膳食摄入量和人体测量指标。采用氧化氘标记法评估母乳摄入量，采集母乳样本测定锌和铁水平，计算婴儿摄入的锌和铁量。在产后4个月测定母亲和婴儿的锌和铁营养状况。
共纳入120名孕妇，80对母婴完成研究（56名纯母乳喂养，24名母乳喂养同时添加婴儿配方奶粉）。所有数据正在进行管理和清理，将进行统计分析。
本研究将提供出生后前4个月纯母乳喂养婴儿锌和铁摄入量的信息，探索预测因素以及锌和铁摄入量与婴儿生长及营养状况之间可能存在的关联。
国际注册报告识别码（IRRID）：DERR1-10.2196/19119。
