School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.
Biochem Soc Trans. 2020 Dec 18;48(6):2579-2589. doi: 10.1042/BST20200310.
Prototissues comprise free-standing 3D networks of interconnected protocell consortia that communicate and display synergistic functions. Significantly, they can be constructed from functional molecules and materials, providing unprecedented opportunities to design tissue-like architectures that can do more than simply mimic living tissues. They could function under extreme conditions and exhibit a wide range of mechanical properties and bio-inspired metabolic functions. In this perspective, I will start by describing recent advancements in the design and synthetic construction of prototissues. I will then discuss the next challenges and the future impact of this emerging research field, which is destined to find applications in the most diverse areas of science and technology, from biomedical science to environmental science, and soft robotics.
原代组织由相互连接的原代细胞联合体组成的独立 3D 网络组成，这些联合体能够进行通信并表现出协同功能。重要的是，它们可以由功能分子和材料构建，这为设计类似组织的结构提供了前所未有的机会，这些结构不仅可以模仿活组织，还可以在极端条件下发挥作用，并表现出广泛的机械性能和仿生代谢功能。在这个视角下，我将首先描述原代组织的设计和合成构建方面的最新进展。然后，我将讨论下一个挑战以及这个新兴研究领域的未来影响，它注定会在从生物医学科学到环境科学和软机器人等各个科学和技术领域找到应用。
