Department of Internal Medicine (Hematology-Oncology), University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Cancer Cell. 2020 Dec 14;38(6):771-773. doi: 10.1016/j.ccell.2020.10.021. Epub 2020 Nov 5.
Gene expression analyses have identified subtypes of conventional renal cell carcinoma broadly distributed into angiogenic and proliferative/ immunogenic clades. Integration with genomic and functional experiments in animal models yields an evolutionary model. Evolutionary trajectories illustrate remarkable plasticity, particularly for a tumor that typically begins with inactivation of a single gene.
基因表达分析已经确定了传统肾细胞癌的亚型,这些亚型广泛分布在血管生成和增殖/免疫群中。与动物模型中的基因组和功能实验相结合,产生了一个进化模型。进化轨迹说明了显著的可塑性,特别是对于通常从单个基因失活开始的肿瘤。